PMID- 26573108
OWN - NLM
STAT- MEDLINE
DCOM- 20160930
LR  - 20190606
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 21
DP  - 2015 Nov 17
TI  - Relation of Angiographic Thrombus Burden with Severity of Coronary Artery Disease 
      in Patients with ST Segment Elevation Myocardial Infarction.
PG  - 3540-6
AB  - BACKGROUND We planned to investigate the relationship of thrombus burden with 
      SYNTAX score in patients with ST elevation myocardial infarction (STEMI). 
      MATERIAL AND METHODS We retrospectively enrolled 780 patients who underwent PPCI 
      in our clinic due to STEMI. Clinical, laboratory, and demographic properties of 
      the patients were recorded. Angiographic coronary thrombus burden was classified 
      using thrombolysis in myocardial infarction (TIMI) thrombus grades. RESULTS 
      Patients with high thrombus burden were older, with higher diabetes prevalence 
      longer pain to balloon time, higher leukocyte count, higher admission troponin, 
      and admission CK-MB concentrations. SYNTAX score was higher and myocardial 
      perfusion grades were lower in patients with high thrombus burden. Multivariate 
      logistic regression analysis revealed SYNTAX score as the strongest predictor of 
      thrombus burden. ROC analysis demonstrated a sensitivity of 75.5%, specificity of 
      61.2%, and cut-off value of >14 (area under the curve (AUC): 0.702; 95% 
      confidence interval [CI]: 0.773-0.874;P<0.001) for high thrombus burden. 
      CONCLUSIONS SYNTAX score may have additional value in predicting higher thrombus 
      burden besides being a marker of coronary artery disease severity and complexity.
FAU - Duman, Hakan
AU  - Duman H
AD  - Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, 
      Rize, Turkey.
FAU - Cetin, Mustafa
AU  - Cetin M
AD  - Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, 
      Rize, Turkey.
FAU - Durakoglugil, Murtaza Emre
AU  - Durakoglugil ME
AD  - Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, 
      Rize, Turkey.
FAU - Degirmenci, Husnu
AU  - Degirmenci H
AD  - Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, 
      Turkey.
FAU - Hamur, Hikmet
AU  - Hamur H
AD  - Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, 
      Turkey.
FAU - Bostan, Mehmet
AU  - Bostan M
AD  - Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, 
      Rize, Turkey.
FAU - Karadag, Zakir
AU  - Karadag Z
AD  - Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, 
      Rize, Turkey.
FAU - Cicek, Yuksel
AU  - Cicek Y
AD  - Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, 
      Rize, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20151117
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Coronary Angiography
MH  - Coronary Artery Disease/blood/*pathology/surgery
MH  - Female
MH  - Forecasting
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/pathology/surgery
MH  - Percutaneous Coronary Intervention
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Thrombosis/blood/*pathology
PMC - PMC4655613
EDAT- 2015/11/18 06:00
MHDA- 2016/10/01 06:00
PMCR- 2015/11/17
CRDT- 2015/11/18 06:00
PHST- 2015/11/18 06:00 [entrez]
PHST- 2015/11/18 06:00 [pubmed]
PHST- 2016/10/01 06:00 [medline]
PHST- 2015/11/17 00:00 [pmc-release]
AID - 895157 [pii]
AID - 10.12659/msm.895157 [doi]
PST - epublish
SO  - Med Sci Monit. 2015 Nov 17;21:3540-6. doi: 10.12659/msm.895157.