PMID- 26573458
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20181113
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 13
IP  - 1
DP  - 2016 Jan
TI  - A comparative analysis of metal allergens associated with dental alloy prostheses 
      and the expression of HLA-DR in gingival tissue.
PG  - 91-8
LID - 10.3892/mmr.2015.4562 [doi]
AB  - The present study aimed to provide guidance for the selection of prosthodontic 
      materials and the management of patients with a suspected metal allergy. This 
      included a comparison of the sensitivity of patients to alloys used in prescribed 
      metal‑containing prostheses, and correlation analysis between metal allergy and 
      accompanying clinical symptoms of sensitized patients using a patch test. The 
      results from the patch test and metal component analyses were processed to reach 
      a final diagnosis. In the present study, four dental alloys were assessed. 
      Subsequent to polishing the surface of a metal restoration, the components were 
      analyzed using an X‑ray fluorescence microscopy and spectrometry. 
      Immunohistochemical analysis, reverse transcription‑polymerase chain reaction and 
      western blotting were used to detect the expression levels of human leukocyte 
      antigen (HLA)‑DR in gingival tissues affected by alloy restoration, and in normal 
      gingival tissue samples. Positive allergens identified in the patch test were 
      consistent with the components of the metal prostheses. The prevalence of nickel 
      (Ni) allergy was highest (22.8%), and women were significantly more allergic to 
      palladium and Ni than men (P<0.05). The protein and gene expression levels of 
      HLA‑DR in the Ni‑chromium (Cr) prosthesis group were significantly higher, 
      compared with those in the other groups (P<0.01); followed by cobalt‑Cr alloy, 
      gold alloy and titanium alloy. In conclusion, dentists require an understanding 
      of the corrosion and allergy rates of prescribed alloys, in order to reduce the 
      risk of allergic reactions. Patch testing for hypersensitive patients is 
      recommended and caution is required when planning to use different alloys in the 
      mouth.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
FAU - Wei, Li-Cheng
AU  - Wei LC
AD  - Department of Orthopaedics, Shanghai Guanghua Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai 200052, P.R. China.
FAU - Wu, Bin
AU  - Wu B
AD  - Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
FAU - Yu, Li-Ying
AU  - Yu LY
AD  - Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
FAU - Wang, Xiao-Ping
AU  - Wang XP
AD  - Department of Stomatology, Yuhuangding Hospital, Yantai, Shandong 264000, P.R. 
      China.
FAU - Liu, Yue
AU  - Liu Y
AD  - Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, 
      P.R. China.
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151112
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Allergens)
RN  - 0 (Dental Alloys)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Metals)
SB  - IM
MH  - Allergens/*adverse effects
MH  - Dental Alloys/*adverse effects
MH  - Dental Prosthesis/adverse effects
MH  - Dental Restoration, Permanent
MH  - Female
MH  - Follow-Up Studies
MH  - Gingiva/*immunology
MH  - HLA-DR Antigens/genetics/*metabolism
MH  - Humans
MH  - Male
MH  - Metals/*adverse effects
MH  - Patch Tests
PMC - PMC4686053
EDAT- 2015/11/18 06:00
MHDA- 2016/09/27 06:00
PMCR- 2015/11/12
CRDT- 2015/11/18 06:00
PHST- 2014/12/26 00:00 [received]
PHST- 2015/09/22 00:00 [accepted]
PHST- 2015/11/18 06:00 [entrez]
PHST- 2015/11/18 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
PHST- 2015/11/12 00:00 [pmc-release]
AID - mmr-13-01-0091 [pii]
AID - 10.3892/mmr.2015.4562 [doi]
PST - ppublish
SO  - Mol Med Rep. 2016 Jan;13(1):91-8. doi: 10.3892/mmr.2015.4562. Epub 2015 Nov 12.