PMID- 26573476
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151124
LR  - 20151117
IS  - 0034-7450 (Print)
IS  - 0034-7450 (Linking)
VI  - 41
IP  - 1
DP  - 2012 Mar
TI  - [Clinical Applications of Peripheral Markers of Response in Antidepressant 
      Treatment: Neurotrophins and Cytokines].
PG  - 165-84
LID - S0034-7450(14)60075-5 [pii]
LID - 10.1016/S0034-7450(14)60075-5 [doi]
AB  - INTRODUCTION: Explanatory theories of depression have advanced in recent decades 
      from the monoaminergic hypothesis to neurogenesis alterations to the 
      neurohormonal hypothesis that includes the dysfunction of the inflammatory 
      response. Currently there is a growing interest in the development of biomarkers 
      that can contribute to diagnosis and proper treatment. OBJECTIVES: To describe 
      the role of neurotrophins such as brain-derived neurotrophic factor (BDNF) and 
      cytokines in the pathophysiology of depressive disorder in addition to reviewing 
      and analyzing evidence about their clinical application as biomarkers of 
      antidepressant therapy. METHOD: Relevant data research in several databases. 
      RESULTS AND CONCLUSIONS: In recent years evidence of alterations in neurogenesis 
      mediated by the expression of BDNF in the hippocampus in the pathophysiology of 
      depression has increased and there is ample evidence that BDNF is a marker of the 
      diagnosis of depressive disorder and also of treatment effectiveness. There is 
      little information about other neurotrophins. There has also been increased 
      interest in relation to depression as an "inflammatory disease" and the link with 
      cytokines in its pathogenesis. Evidence has been found for the usefulness of some 
      cytokines especially IL-1 (interleukin 1), IL-6 (interleukin 6), and TNF (tumor 
      necrosis factor) as biomarkers of antidepressant drug response in humans.
CI  - Copyright (c) 2012 Asociacion Colombiana de Psiquiatria. Publicado por Elsevier 
      Espana. All rights reserved.
FAU - Bermudez, Constanza Mendoza
AU  - Bermudez CM
AD  - Medica psiquiatra, estudiante del Doctorado en Salud Mental, Universidad de 
      Concepcion, Concepcion, Chile. Electronic address: constanzamendozab@gmail.com.
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Aplicacion clinica de marcadores perifericos de respuesta a la terapia 
      antidepresiva: neurotrofinas y citocinas.
DEP - 20140510
PL  - Colombia
TA  - Rev Colomb Psiquiatr
JT  - Revista colombiana de psiquiatria
JID - 0045130
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Factor neurotrofico derivado del cerebro
OT  - biomarcadores
OT  - biomarkers
OT  - citocinas
OT  - cytokines
OT  - depresion
OT  - depression
OT  - neurotrofinas
OT  - neurotrophins
EDAT- 2012/03/01 00:00
MHDA- 2012/03/01 00:01
CRDT- 2015/11/18 06:00
PHST- 2011/11/02 00:00 [received]
PHST- 2012/02/10 00:00 [accepted]
PHST- 2015/11/18 06:00 [entrez]
PHST- 2012/03/01 00:00 [pubmed]
PHST- 2012/03/01 00:01 [medline]
AID - S0034-7450(14)60075-5 [pii]
AID - 10.1016/S0034-7450(14)60075-5 [doi]
PST - ppublish
SO  - Rev Colomb Psiquiatr. 2012 Mar;41(1):165-84. doi: 10.1016/S0034-7450(14)60075-5. 
      Epub 2014 May 10.