PMID- 26575319
OWN - NLM
STAT- MEDLINE
DCOM- 20160613
LR  - 20160122
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 63
IP  - 3
DP  - 2016 Mar
TI  - Prevalence of Developmental Delay and Contributing Factors Among Children With 
      Sickle Cell Disease.
PG  - 504-10
LID - 10.1002/pbc.25838 [doi]
AB  - BACKGROUND: Children with sickle cell disease (SCD) are at higher risk for 
      deficits in cognition compared to the general population, even at young ages. 
      Disease severity has been co-assessed in earlier studies, but the home 
      environment has not. The purpose of the current study was to investigate the 
      development of young children with SCD and secondarily, the impact of 
      environmental and family factors. METHODS: The current study is a baseline 
      cross-sectional evaluation of a prospective, single-center cohort. Children with 
      SCD between the ages of 1 and 42 months and their primary caregiver were 
      included. Participants lived within 30 miles of the site and spoke English. 
      Children underwent developmental evaluation using the Bayley Scales of Infant and 
      Toddler Development, Third Edition (BSID-III). Home visits were completed and 
      screened using the Home Observation for Measurement of the Environment (HOME). 
      RESULTS: Over 3 years, 43 caregiver-child dyads consented and participated. Over 
      50% of children scored significantly below average on cognition and expressive 
      language subscales. SCD severity was not associated with BSID-III scores. 
      Socioeconomic status (SES) determined by the Diez-Roux method positively 
      correlated (r = 0.401, P < 0.01) with the home environment. The HOME correlated 
      (r = 0.360, P < 0.05) with the cognitive subscale on the BSID-III. CONCLUSIONS: 
      Given the high prevalence of developmental delay in this population, identifying 
      modifiable factors to maximize developmental progress is essential. The home 
      environment would be a targeted method for intervention. Future research is 
      needed to identify the benefits of home-based intervention for this population.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Drazen, Catherine Hoyt
AU  - Drazen CH
AD  - Program in Occupational Therapy, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Abel, Regina
AU  - Abel R
AD  - Program in Occupational Therapy, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Gabir, Mohamed
AU  - Gabir M
AD  - Program in Occupational Therapy, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Farmer, Grant
AU  - Farmer G
AD  - Division of Public Health Sciences, Department of Surgery, Washington University 
      School of Medicine, St. Louis, Missouri.
FAU - King, Allison A
AU  - King AA
AD  - Program in Occupational Therapy, Washington University School of Medicine, St. 
      Louis, Missouri.
AD  - Division of Public Health Sciences, Department of Surgery, Washington University 
      School of Medicine, St. Louis, Missouri.
AD  - Department of Pediatrics Hematology/Oncology, St. Louis Children's Hospital, 
      Washington University School of Medicine, St. Louis, Missouri.
LA  - eng
GR  - H46MC09231/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20151117
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - Anemia, Sickle Cell/*complications
MH  - Child, Preschool
MH  - Cognition Disorders/*etiology
MH  - Cross-Sectional Studies
MH  - Developmental Disabilities/*etiology
MH  - Family
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prospective Studies
OTO - NOTNLM
OT  - cognition
OT  - development
OT  - home environment
OT  - sickle cell disease
EDAT- 2015/11/18 06:00
MHDA- 2016/06/14 06:00
CRDT- 2015/11/18 06:00
PHST- 2015/08/12 00:00 [received]
PHST- 2015/10/16 00:00 [accepted]
PHST- 2015/11/18 06:00 [entrez]
PHST- 2015/11/18 06:00 [pubmed]
PHST- 2016/06/14 06:00 [medline]
AID - 10.1002/pbc.25838 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2016 Mar;63(3):504-10. doi: 10.1002/pbc.25838. Epub 2015 
      Nov 17.