PMID- 26575696
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20161230
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 6
IP  - 1
DP  - 2016 Jan
TI  - The effects of house dust mite sublingual immunotherapy in patients with allergic 
      rhinitis according to duration.
PG  - 82-7
LID - 10.1002/alr.21657 [doi]
AB  - BACKGROUND: The safety and efficacy of sublingual immunotherapy (SLIT) have been 
      demonstrated in the recent 2 decades. However, the data is still mixed regarding 
      the efficacy of house dust mite (HDM) SLIT. The objective of this work was to 
      evaluate the different clinical efficacy SLIT in patients with allergic rhinitis 
      (AR) according to different durations of treatment. METHODS: A total of 500 
      subjects with HDM-induced AR were randomized to receive SLIT with 
      Dermatophagoides farinae (Der.f) drops or pharmacotherapy with oral 
      antihistamines. Patients in the SLIT group were further divided into SLIT1, 
      SLIT2, and SLIT3 subgroups. After SLIT completion, a yearly follow-up visit was 
      given to patients in the SLIT1 and SLIT2 subgroups. The total nasal symptom score 
      (TNSS), the proportion of medication withdrawal, the visual analogue scale (VAS) 
      score, and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores were 
      assessed at each monthly visit. RESULTS: Comparing with the baseline value, TNSS, 
      VAS, and RQLQ were significantly improved in 3 SLIT subgroups after treatment (p 
      < 0.05). In addition, patients in SLIT3 subgroup achieved the highest proportion 
      of medication withdrawal compared to the SLIT1 and SLIT2 subgroups (p < 0.05). 
      After 1-year follow-up, no significant differences were observed in TNSS, VAS 
      scores, and the proportion of medication withdrawal of SLIT1 and SLIT2 subgroups 
      (p > 0.05) with respect to the completion value. No severe systemic adverse 
      events (AEs) were reported. CONCLUSION: The randomized study suggested that 
      3-year courses of SLIT in patients with AR was more efficacious than 1-year or 
      2-year courses. Furthermore, patients achieved 1-year long-term clinical benefits 
      from HDM SLIT.
CI  - (c) 2015 ARS-AAOA, LLC.
FAU - Lin, Zhibin
AU  - Lin Z
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Liu, Qihong
AU  - Liu Q
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Li, Tianying
AU  - Li T
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Chen, Dong
AU  - Chen D
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Chen, Dehua
AU  - Chen D
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Xu, Rui
AU  - Xu R
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20151117
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Child
MH  - Child, Preschool
MH  - Dermatophagoides farinae/*immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - Rhinitis, Allergic, Perennial/immunology/*therapy
MH  - Sublingual Immunotherapy/*methods
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Dermatophagoides farinae drops
OT  - allergic rhinitis
OT  - duration
OT  - house dust mite
OT  - long-term clinical benefits
OT  - sublingual immunotherapy
EDAT- 2015/11/18 06:00
MHDA- 2016/10/12 06:00
CRDT- 2015/11/18 06:00
PHST- 2014/09/18 00:00 [received]
PHST- 2015/08/06 00:00 [revised]
PHST- 2015/09/01 00:00 [accepted]
PHST- 2015/11/18 06:00 [entrez]
PHST- 2015/11/18 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
AID - 10.1002/alr.21657 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2016 Jan;6(1):82-7. doi: 10.1002/alr.21657. Epub 2015 
      Nov 17.