PMID- 26577017
OWN - NLM
STAT- MEDLINE
DCOM- 20170526
LR  - 20171205
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 104
DP  - 2016 May
TI  - Purine nucleosides in neuroregeneration and neuroprotection.
PG  - 226-42
LID - S0028-3908(15)30170-2 [pii]
LID - 10.1016/j.neuropharm.2015.11.006 [doi]
AB  - In the present review, we stress the importance of the purine nucleosides, 
      adenosine and guanosine, in protecting the nervous system, both centrally and 
      peripherally, via activation of their receptors and intracellular signalling 
      mechanisms. A most novel part of the review focus on the mechanisms of neuronal 
      regeneration that are targeted by nucleosides, including a recently identified 
      action of adenosine on axonal growth and microtubule dynamics. Discussion on the 
      role of the purine nucleosides transversally with the most established 
      neurotrophic factors, e.g. brain derived neurotrophic factor (BDNF), glial 
      derived neurotrophic factor (GDNF), is also focused considering the intimate 
      relationship between some adenosine receptors, as is the case of the A2A 
      receptors, and receptors for neurotrophins. This article is part of the Special 
      Issue entitled 'Purines in Neurodegeneration and Neuroregeneration'.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Ribeiro, Filipa F
AU  - Ribeiro FF
AD  - Instituto de Farmacologia e Neurociencias, Faculdade de Medicina, Universidade de 
      Lisboa, Lisboa, Portugal; Instituto de Medicina Molecular, Faculdade de Medicina, 
      Universidade de Lisboa, Lisboa, Portugal.
FAU - Xapelli, Sara
AU  - Xapelli S
AD  - Instituto de Farmacologia e Neurociencias, Faculdade de Medicina, Universidade de 
      Lisboa, Lisboa, Portugal; Instituto de Medicina Molecular, Faculdade de Medicina, 
      Universidade de Lisboa, Lisboa, Portugal.
FAU - Miranda-Lourenco, Catarina
AU  - Miranda-Lourenco C
AD  - Instituto de Farmacologia e Neurociencias, Faculdade de Medicina, Universidade de 
      Lisboa, Lisboa, Portugal; Instituto de Medicina Molecular, Faculdade de Medicina, 
      Universidade de Lisboa, Lisboa, Portugal.
FAU - Tanqueiro, Sara R
AU  - Tanqueiro SR
AD  - Instituto de Farmacologia e Neurociencias, Faculdade de Medicina, Universidade de 
      Lisboa, Lisboa, Portugal; Instituto de Medicina Molecular, Faculdade de Medicina, 
      Universidade de Lisboa, Lisboa, Portugal.
FAU - Fonseca-Gomes, Joao
AU  - Fonseca-Gomes J
AD  - Instituto de Farmacologia e Neurociencias, Faculdade de Medicina, Universidade de 
      Lisboa, Lisboa, Portugal; Instituto de Medicina Molecular, Faculdade de Medicina, 
      Universidade de Lisboa, Lisboa, Portugal.
FAU - Diogenes, Maria J
AU  - Diogenes MJ
AD  - Instituto de Farmacologia e Neurociencias, Faculdade de Medicina, Universidade de 
      Lisboa, Lisboa, Portugal; Instituto de Medicina Molecular, Faculdade de Medicina, 
      Universidade de Lisboa, Lisboa, Portugal.
FAU - Ribeiro, Joaquim A
AU  - Ribeiro JA
AD  - Instituto de Farmacologia e Neurociencias, Faculdade de Medicina, Universidade de 
      Lisboa, Lisboa, Portugal; Instituto de Medicina Molecular, Faculdade de Medicina, 
      Universidade de Lisboa, Lisboa, Portugal.
FAU - Sebastiao, Ana M
AU  - Sebastiao AM
AD  - Instituto de Farmacologia e Neurociencias, Faculdade de Medicina, Universidade de 
      Lisboa, Lisboa, Portugal; Instituto de Medicina Molecular, Faculdade de Medicina, 
      Universidade de Lisboa, Lisboa, Portugal. Electronic address: 
      anaseb@medicina.ulisboa.pt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151111
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Purinergic P1)
RN  - 12133JR80S (Guanosine)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/*metabolism
MH  - Animals
MH  - Axon Guidance
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Central Nervous System/*metabolism
MH  - Encephalitis/metabolism
MH  - Guanosine/*metabolism
MH  - Humans
MH  - Neurogenesis
MH  - Neuroglia/metabolism
MH  - Neurons/*metabolism
MH  - Oxidative Stress
MH  - Peripheral Nervous System/*metabolism
MH  - Receptors, Purinergic P1/*metabolism
MH  - *Regeneration
MH  - Synapses/metabolism
OTO - NOTNLM
OT  - Adenosine
OT  - Axon growth
OT  - Guanosine
OT  - Neuroprotection
OT  - Neurotrophic factors
OT  - Regeneration
EDAT- 2015/11/19 06:00
MHDA- 2017/05/27 06:00
CRDT- 2015/11/19 06:00
PHST- 2015/08/07 00:00 [received]
PHST- 2015/11/05 00:00 [revised]
PHST- 2015/11/06 00:00 [accepted]
PHST- 2015/11/19 06:00 [entrez]
PHST- 2015/11/19 06:00 [pubmed]
PHST- 2017/05/27 06:00 [medline]
AID - S0028-3908(15)30170-2 [pii]
AID - 10.1016/j.neuropharm.2015.11.006 [doi]
PST - ppublish
SO  - Neuropharmacology. 2016 May;104:226-42. doi: 10.1016/j.neuropharm.2015.11.006. 
      Epub 2015 Nov 11.