PMID- 26577179
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20181202
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 11
IP  - 12
DP  - 2015
TI  - Activation of chaperone-mediated autophagy as a potential anticancer therapy.
PG  - 2370-1
LID - 10.1080/15548627.2015.1106666 [doi]
AB  - Chaperone-mediated autophagy (CMA), a subtype of autophagy, delivers select 
      proteins into the lysosome for degradation. Defects in CMA activity have 
      previously been linked with neurodegenerative diseases due to the accumulation of 
      misfolded proteins, but the role of CMA in cancer is currently not well defined. 
      In a recent study, we provide a novel mechanism by which excessive activation of 
      CMA can be exploited as a method to eliminate cancer cells by inducing metabolic 
      catastrophe and delineate a novel strategy to promote the degradation of HK2 
      (hexokinase 2) in cancer cells.
FAU - Galan-Acosta, Lorena
AU  - Galan-Acosta L
AD  - a Division of Toxicology; Institute of Environmental Medicine; Karolinska 
      Institutet ; Stockholm , Sweden.
FAU - Xia, Hongguang
AU  - Xia H
AD  - b Department of Cell Biology ; Harvard Medical School ; Boston , MA USA.
FAU - Yuan, Junying
AU  - Yuan J
AD  - b Department of Cell Biology ; Harvard Medical School ; Boston , MA USA.
FAU - Vakifahmetoglu-Norberg, Helin
AU  - Vakifahmetoglu-Norberg H
AD  - a Division of Toxicology; Institute of Environmental Medicine; Karolinska 
      Institutet ; Stockholm , Sweden.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 0 (Molecular Chaperones)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.10.1 (fms-Like Tyrosine Kinase 3)
SB  - IM
CON - J Cell Biol. 2015 Aug 31;210(5):705-16. PMID: 26323688
MH  - Autophagy/*physiology
MH  - Hexokinase/*metabolism
MH  - Humans
MH  - Leukemia, Myeloid/*enzymology/*pathology
MH  - Molecular Chaperones/*metabolism
MH  - *Proteolysis
MH  - fms-Like Tyrosine Kinase 3/*antagonists & inhibitors
PMC - PMC4835192
OTO - NOTNLM
OT  - autophagy
OT  - cancer
OT  - chaperone-mediated autophagy
OT  - hexokinase-2
OT  - metabolism
EDAT- 2015/11/19 06:00
MHDA- 2016/05/03 06:00
PMCR- 2016/11/17
CRDT- 2015/11/19 06:00
PHST- 2015/11/19 06:00 [entrez]
PHST- 2015/11/19 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2016/11/17 00:00 [pmc-release]
AID - 1106666 [pii]
AID - 10.1080/15548627.2015.1106666 [doi]
PST - ppublish
SO  - Autophagy. 2015;11(12):2370-1. doi: 10.1080/15548627.2015.1106666.