PMID- 26578601 OWN - NLM STAT- MEDLINE DCOM- 20160613 LR - 20220317 IS - 1362-4962 (Electronic) IS - 0305-1048 (Print) IS - 0305-1048 (Linking) VI - 44 IP - D1 DP - 2016 Jan 4 TI - Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information. PG - D1069-74 LID - 10.1093/nar/gkv1230 [doi] AB - Extensive drug discovery efforts have yielded many approved and candidate drugs targeting various targets in different biological pathways. Several freely accessible databases provide the drug, target and drug-targeted pathway information for facilitating drug discovery efforts, but there is an insufficient coverage of the clinical trial drugs and the drug-targeted pathways. Here, we describe an update of the Therapeutic Target Database (TTD) previously featured in NAR. The updated contents include: (i) significantly increased coverage of the clinical trial targets and drugs (1.6 and 2.3 times of the previous release, respectively), (ii) cross-links of most TTD target and drug entries to the corresponding pathway entries of KEGG, MetaCyc/BioCyc, NetPath, PANTHER pathway, Pathway Interaction Database (PID), PathWhiz, Reactome and WikiPathways, (iii) the convenient access of the multiple targets and drugs cross-linked to each of these pathway entries and (iv) the recently emerged approved and investigative drugs. This update makes TTD a more useful resource to complement other databases for facilitating the drug discovery efforts. TTD is accessible at http://bidd.nus.edu.sg/group/ttd/ttd.asp. CI - (c) The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. FAU - Yang, Hong AU - Yang H AD - Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China. FAU - Qin, Chu AU - Qin C AD - Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore. FAU - Li, Ying Hong AU - Li YH AD - Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China. FAU - Tao, Lin AU - Tao L AD - Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore. FAU - Zhou, Jin AU - Zhou J AD - Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China. FAU - Yu, Chun Yan AU - Yu CY AD - Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China. FAU - Xu, Feng AU - Xu F AD - College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, P. R. China. FAU - Chen, Zhe AU - Chen Z AD - Zhejiang Key Laboratory of Gastro-intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, China. FAU - Zhu, Feng AU - Zhu F AD - Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China zhufeng@cqu.edu.cn. FAU - Chen, Yu Zong AU - Chen YZ AD - Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543, Singapore csccyz@nus.edu.sg. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151117 PL - England TA - Nucleic Acids Res JT - Nucleic acids research JID - 0411011 SB - IM MH - Clinical Trials as Topic MH - *Databases, Pharmaceutical MH - *Drug Discovery MH - Internet MH - Signal Transduction/drug effects PMC - PMC4702870 EDAT- 2015/11/19 06:00 MHDA- 2016/06/14 06:00 PMCR- 2015/11/17 CRDT- 2015/11/19 06:00 PHST- 2015/10/30 00:00 [accepted] PHST- 2015/09/19 00:00 [received] PHST- 2015/11/19 06:00 [entrez] PHST- 2015/11/19 06:00 [pubmed] PHST- 2016/06/14 06:00 [medline] PHST- 2015/11/17 00:00 [pmc-release] AID - gkv1230 [pii] AID - 10.1093/nar/gkv1230 [doi] PST - ppublish SO - Nucleic Acids Res. 2016 Jan 4;44(D1):D1069-74. doi: 10.1093/nar/gkv1230. Epub 2015 Nov 17.