PMID- 26578933
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151120
LR  - 20200930
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 9
DP  - 2015
TI  - Anterior cingulate cortex-related connectivity in first-episode schizophrenia: a 
      spectral dynamic causal modeling study with functional magnetic resonance 
      imaging.
PG  - 589
LID - 10.3389/fnhum.2015.00589 [doi]
LID - 589
AB  - Understanding the neural basis of schizophrenia (SZ) is important for shedding 
      light on the neurobiological mechanisms underlying this mental disorder. 
      Structural and functional alterations in the anterior cingulate cortex (ACC), 
      dorsolateral prefrontal cortex (DLPFC), hippocampus, and medial prefrontal cortex 
      (MPFC) have been implicated in the neurobiology of SZ. However, the effective 
      connectivity among them in SZ remains unclear. The current study investigated how 
      neuronal pathways involving these regions were affected in first-episode SZ using 
      functional magnetic resonance imaging (fMRI). Forty-nine patients with a 
      first-episode of psychosis and diagnosis of SZ-according to the Diagnostic and 
      Statistical Manual of Mental Disorders, Fourth Edition, Text Revision-were 
      studied. Fifty healthy controls (HCs) were included for comparison. All subjects 
      underwent resting state fMRI. We used spectral dynamic causal modeling (DCM) to 
      estimate directed connections among the bilateral ACC, DLPFC, hippocampus, and 
      MPFC. We characterized the differences using Bayesian parameter averaging (BPA) 
      in addition to classical inference (t-test). In addition to common effective 
      connectivity in these two groups, HCs displayed widespread significant 
      connections predominantly involved in ACC not detected in SZ patients, but SZ 
      showed few connections. Based on BPA results, SZ patients exhibited anterior 
      cingulate cortico-prefrontal-hippocampal hyperconnectivity, as well as 
      ACC-related and hippocampal-dorsolateral prefrontal-medial prefrontal 
      hypoconnectivity. In summary, spectral DCM revealed the pattern of effective 
      connectivity involving ACC in patients with first-episode SZ. This study provides 
      a potential link between SZ and dysfunction of ACC, creating an ideal situation 
      to associate mechanisms behind SZ with aberrant connectivity among these 
      cognition and emotion-related regions.
FAU - Cui, Long-Biao
AU  - Cui LB
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - Liu, Jian
AU  - Liu J
AD  - Network Center, The Fourth Military Medical University Xi'an, China.
FAU - Wang, Liu-Xian
AU  - Wang LX
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - Li, Chen
AU  - Li C
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - Xi, Yi-Bin
AU  - Xi YB
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - Guo, Fan
AU  - Guo F
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - Wang, Hua-Ning
AU  - Wang HN
AD  - Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - Zhang, Lin-Chuan
AU  - Zhang LC
AD  - School of Biomedical Engineering, The Fourth Military Medical University Xi'an, 
      China.
FAU - Liu, Wen-Ming
AU  - Liu WM
AD  - Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - He, Hong
AU  - He H
AD  - Department of Psychiatry, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - Tian, Ping
AU  - Tian P
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - Yin, Hong
AU  - Yin H
AD  - Department of Radiology, Xijing Hospital, The Fourth Military Medical University 
      Xi'an, China.
FAU - Lu, Hongbing
AU  - Lu H
AD  - School of Biomedical Engineering, The Fourth Military Medical University Xi'an, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20151103
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC4630283
OTO - NOTNLM
OT  - anterior cingulate cortex
OT  - effective connectivity
OT  - functional magnetic resonance imaging
OT  - schizophrenia
OT  - spectral dynamic causal modeling
EDAT- 2015/11/19 06:00
MHDA- 2015/11/19 06:01
PMCR- 2015/01/01
CRDT- 2015/11/19 06:00
PHST- 2015/06/08 00:00 [received]
PHST- 2015/10/12 00:00 [accepted]
PHST- 2015/11/19 06:00 [entrez]
PHST- 2015/11/19 06:00 [pubmed]
PHST- 2015/11/19 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2015.00589 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2015 Nov 3;9:589. doi: 10.3389/fnhum.2015.00589. eCollection 
      2015.