PMID- 26579318
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151120
LR  - 20200930
IS  - 2090-6560 (Print)
IS  - 2090-6579 (Electronic)
IS  - 2090-6579 (Linking)
VI  - 2015
DP  - 2015
TI  - Heparin-Induced Thrombocytopenia in a Patient with Essential Thrombocythemia: A 
      Case Based Update.
PG  - 985253
LID - 10.1155/2015/985253 [doi]
LID - 985253
AB  - Vascular thrombosis is a common clinical feature of both essential 
      thrombocythemia (ET) and heparin-induced thrombocytopenia (HIT). The development 
      of HIT in a patient with ET is rare and underrecognized. We report the case of a 
      77-year-old woman with preexisting ET, who was admitted with acute coronary 
      syndrome, and IV heparin was started. She was exposed to unfractionated heparin 
      (UFH) 5 days prior to this admission. Decrease in platelet count was noted, and 
      HIT panel was sent. Heparin was discontinued. Patient developed atrial 
      fibrillation, and Dabigatran was started. On day three, patient also developed 
      multiple tiny cerebral infarctions and acute right popliteal DVT. On day ten of 
      admission, HIT panel was positive, and Dabigatran was changed to Lepirudin. Two 
      days later, Lepirudin was also discontinued because patient developed 
      pseudoaneurysm on the right common femoral artery at the site of cardiac 
      catheterization access. A progressive increase in the platelet count was noted 
      after discontinuing heparin. Physicians should be aware of the coexistence of HIT 
      and ET, accompanied challenges of the prompt diagnosis, and initiation of 
      appropriate treatment.
FAU - Noel, Edva
AU  - Noel E
AD  - Department of Medicine, Bronx Lebanon Hospital Center, 1650 Selwyn Avenue, Suite 
      No. 15H, Bronx, NY 10457, USA.
FAU - Abbas, Naeem
AU  - Abbas N
AD  - Department of Gastroenterology, Bronx Lebanon Hospital Center, 1650 Selwyn 
      Avenue, Suite No. 10C, Bronx, NY 10457, USA.
FAU - Skaradinskiy, Yevegeniy
AU  - Skaradinskiy Y
AD  - Department of Hematology, Bronx Lebanon Hospital Center, 1650 Selwyn Avenue, 
      Suite No. 2C, Bronx, NY 10457, USA.
FAU - Schreiber, Zwi
AU  - Schreiber Z
AD  - Department of Hematology, Bronx Lebanon Hospital Center, 1650 Selwyn Avenue, 
      Suite No. 2C, Bronx, NY 10457, USA.
LA  - eng
PT  - Journal Article
DEP - 20151022
PL  - United States
TA  - Case Rep Hematol
JT  - Case reports in hematology
JID - 101576456
PMC - PMC4633557
EDAT- 2015/11/19 06:00
MHDA- 2015/11/19 06:01
PMCR- 2015/10/22
CRDT- 2015/11/19 06:00
PHST- 2015/06/07 00:00 [received]
PHST- 2015/09/16 00:00 [revised]
PHST- 2015/09/17 00:00 [accepted]
PHST- 2015/11/19 06:00 [entrez]
PHST- 2015/11/19 06:00 [pubmed]
PHST- 2015/11/19 06:01 [medline]
PHST- 2015/10/22 00:00 [pmc-release]
AID - 10.1155/2015/985253 [doi]
PST - ppublish
SO  - Case Rep Hematol. 2015;2015:985253. doi: 10.1155/2015/985253. Epub 2015 Oct 22.