PMID- 26579539
OWN - NLM
STAT- MEDLINE
DCOM- 20160829
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Computational and Pharmacological Target of Neurovascular Unit for Drug Design 
      and Delivery.
PG  - 731292
LID - 10.1155/2015/731292 [doi]
LID - 731292
AB  - The blood-brain barrier (BBB) is a dynamic and highly selective permeable 
      interface between central nervous system (CNS) and periphery that regulates the 
      brain homeostasis. Increasing evidences of neurological disorders and restricted 
      drug delivery process in brain make BBB as special target for further study. At 
      present, neurovascular unit (NVU) is a great interest and highlighted topic of 
      pharmaceutical companies for CNS drug design and delivery approaches. Some recent 
      advancement of pharmacology and computational biology makes it convenient to 
      develop drugs within limited time and affordable cost. In this review, we briefly 
      introduce current understanding of the NVU, including molecular and cellular 
      composition, physiology, and regulatory function. We also discuss the recent 
      technology and interaction of pharmacogenomics and bioinformatics for drug design 
      and step towards personalized medicine. Additionally, we develop gene network due 
      to understand NVU associated transporter proteins interactions that might be 
      effective for understanding aetiology of neurological disorders and new target 
      base protective therapies development and delivery.
FAU - Islam, Md Mirazul
AU  - Islam MM
AD  - Pharmacogenomics Lab, Department of Pharmacology, University of Malaya, 50603 
      Kuala Lumpur, Malaysia.
FAU - Mohamed, Zahurin
AU  - Mohamed Z
AD  - Pharmacogenomics Lab, Department of Pharmacology, University of Malaya, 50603 
      Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151022
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*metabolism
MH  - Computer Simulation
MH  - Drug Delivery Systems/*methods
MH  - *Drug Design
MH  - Humans
MH  - *Models, Biological
MH  - Neurovascular Coupling/drug effects/*physiology
MH  - *Pharmacokinetics
PMC - PMC4633536
EDAT- 2015/11/19 06:00
MHDA- 2016/08/30 06:00
PMCR- 2015/10/22
CRDT- 2015/11/19 06:00
PHST- 2015/08/19 00:00 [received]
PHST- 2015/10/04 00:00 [revised]
PHST- 2015/10/04 00:00 [accepted]
PHST- 2015/11/19 06:00 [entrez]
PHST- 2015/11/19 06:00 [pubmed]
PHST- 2016/08/30 06:00 [medline]
PHST- 2015/10/22 00:00 [pmc-release]
AID - 10.1155/2015/731292 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:731292. doi: 10.1155/2015/731292. Epub 2015 Oct 22.