PMID- 26579541
OWN - NLM
STAT- MEDLINE
DCOM- 20160829
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Pentraxin-3 Predicts Long-Term Cardiac Events in Patients with Chronic Heart 
      Failure.
PG  - 817615
LID - 10.1155/2015/817615 [doi]
LID - 817615
AB  - The aim of this study was to investigate the long-term prognostic value of 
      pentraxin-3 (PTX3) in patients with chronic heart failure (CHF). 377 patients 
      were prospectively followed up for 3 years to determine cardiac events including 
      cardiac death or rehospitalization for worsening heart failure. The plasma PTX3 
      levels were significantly higher in CHF patients than in healthy subjects (p < 
      0.001), and they increased with advancing New York Heart Association (NYHA) 
      Functional Classification (p < 0.001). Plasma PTX3 levels in CHF patients with 
      cardiac events were significantly higher than in event-free patients (p < 0.001). 
      We determined the normal upper limit of plasma PTX3 levels from the mean + 2 SD 
      value of 64 control subjects (3.64 ng/mL). A Kaplan-Meier analysis revealed that 
      patients with increased PTX3 (>/= 3.64 ng/mL) were at a higher risk for cardiac 
      events than those without increased PTX3 (p < 0.01). A multifactorial Cox 
      proportional hazards model showed that increased PTX3 ( >/= 3.64 ngImL) was an 
      independent risk factor for cardiac events in CHF patients (hazard ratio (HR) = 
      4.224, p < 0.01; 95% CI: 1.130-15.783). Plasma PTX3 levels are a long-term 
      independent predictor of prognosis in patients with CHF.
FAU - Liu, Haibo
AU  - Liu H
AD  - Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan 
      University, Shanghai 200032, China ; Department of Cardiology, Yinzhou People's 
      Hospital, Medical School of Ningbo University, Ningbo 315040, China.
FAU - Guo, Xiaofang
AU  - Guo X
AD  - Clinical Laboratory Center, Yinzhou People's Hospital, Medical School of Ningbo 
      University, Ningbo 315040, China.
FAU - Yao, Kang
AU  - Yao K
AD  - Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan 
      University, Shanghai 200032, China.
FAU - Wang, Chunming
AU  - Wang C
AD  - Department of Cardiology, Yinzhou People's Hospital, Medical School of Ningbo 
      University, Ningbo 315040, China.
FAU - Chen, Guozhong
AU  - Chen G
AD  - Department of Cardiology, Yinzhou People's Hospital, Medical School of Ningbo 
      University, Ningbo 315040, China.
FAU - Gao, Wei
AU  - Gao W
AD  - Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan 
      University, Shanghai 200032, China.
FAU - Yuan, Jie
AU  - Yuan J
AD  - Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan 
      University, Shanghai 200032, China.
FAU - Yu, Wangjun
AU  - Yu W
AD  - Clinical Laboratory Center, Yinzhou People's Hospital, Medical School of Ningbo 
      University, Ningbo 315040, China.
FAU - Ge, Junbo
AU  - Ge J
AD  - Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan 
      University, Shanghai 200032, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151022
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biomarkers)
RN  - 0 (Serum Amyloid P-Component)
RN  - 148591-49-5 (PTX3 protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - China/epidemiology
MH  - Chronic Disease
MH  - Death, Sudden, Cardiac/*epidemiology
MH  - Female
MH  - Heart Failure/*blood/diagnosis/*mortality
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Risk Assessment/methods
MH  - Sensitivity and Specificity
MH  - Serum Amyloid P-Component/*analysis
MH  - Survival Rate
PMC - PMC4633533
EDAT- 2015/11/19 06:00
MHDA- 2016/08/30 06:00
PMCR- 2015/10/22
CRDT- 2015/11/19 06:00
PHST- 2015/07/23 00:00 [received]
PHST- 2015/09/13 00:00 [revised]
PHST- 2015/10/05 00:00 [accepted]
PHST- 2015/11/19 06:00 [entrez]
PHST- 2015/11/19 06:00 [pubmed]
PHST- 2016/08/30 06:00 [medline]
PHST- 2015/10/22 00:00 [pmc-release]
AID - 10.1155/2015/817615 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:817615. doi: 10.1155/2015/817615. Epub 2015 Oct 22.