PMID- 26579955
OWN - NLM
STAT- MEDLINE
DCOM- 20160314
LR  - 20151215
IS  - 0279-1072 (Print)
IS  - 0279-1072 (Linking)
VI  - 47
IP  - 5
DP  - 2015 Nov-Dec
TI  - The Psychopharmacology of +/-3,4 Methylenedioxymethamphetamine and its Role in the 
      Treatment of Posttraumatic Stress Disorder.
PG  - 337-44
LID - 10.1080/02791072.2015.1094156 [doi]
AB  - Prior to 1985, +/-3,4-methylenedioxymethamphetamine (MDMA) was readily used as a 
      psychotherapeutic adjunct. As MDMA became popular in treating various psychiatric 
      illnesses by mental health professionals, the public started to abuse the 
      MDMA-containing recreational drug "ecstasy." This alarmed the DEA, which led to 
      emergency scheduling of MDMA as a Schedule I drug. Due to its scheduling in 1985, 
      human research and clinical use has been limited. The majority of research on 
      MDMA has been focused on the drug's potential harmful effects rather than its 
      possible therapeutic effects. The limitations on retrospective human studies and 
      preclinical animal models of MDMA neurotoxicity are examined in this analysis. 
      New research has shown that MDMA, used as a catalyst in psychotherapy, is 
      effective in treating posttraumatic stress disorder (PTSD). This review also 
      examines the psychopharmacological basis for the efficacy of MDMA-assisted 
      psychotherapy. Specifically, the brain regions involved with both PTSD and those 
      activated by MDMA (i.e., amygdala, anterior cingulate cortex, and hippocampus) 
      are examined. Also, the possible neurochemical mechanisms involved in MDMA's 
      efficacy in treating PTSD are reviewed.
FAU - Amoroso, Timothy
AU  - Amoroso T
AD  - a Research Assistant, Department of Psychology , University of New Hampshire , 
      Durham , NH.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151118
PL  - United States
TA  - J Psychoactive Drugs
JT  - Journal of psychoactive drugs
JID - 8113536
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Cognition Disorders/chemically induced
MH  - Humans
MH  - N-Methyl-3,4-methylenedioxyamphetamine/adverse effects/*pharmacology/therapeutic 
      use
MH  - Stress Disorders, Post-Traumatic/*drug therapy
OTO - NOTNLM
OT  - MDMA
OT  - MDMA-assisted psychotherapy
OT  - PTSD
OT  - posttraumatic stress disorder
EDAT- 2015/11/19 06:00
MHDA- 2016/03/15 06:00
CRDT- 2015/11/19 06:00
PHST- 2015/11/19 06:00 [entrez]
PHST- 2015/11/19 06:00 [pubmed]
PHST- 2016/03/15 06:00 [medline]
AID - 10.1080/02791072.2015.1094156 [doi]
PST - ppublish
SO  - J Psychoactive Drugs. 2015 Nov-Dec;47(5):337-44. doi: 
      10.1080/02791072.2015.1094156. Epub 2015 Nov 18.