PMID- 26580570
OWN - NLM
STAT- MEDLINE
DCOM- 20160809
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 190
DP  - 2016 Jan 15
TI  - Cortical inhibitory and excitatory correlates of depression severity in children 
      and adolescents.
PG  - 566-575
LID - S0165-0327(15)30816-8 [pii]
LID - 10.1016/j.jad.2015.10.020 [doi]
AB  - OBJECTIVES: Neurophysiologic correlates of depression severity potentially have 
      great utility in diagnosis and treatment planning. Transcranial magnetic 
      stimulation (TMS) measures of cortical inhibition and excitability have shown 
      promise as biomarkers in psychiatry, but no prior work has examined correlates of 
      illness severity in pediatric mood disorders. This study sought to examine the 
      relationship between depression severity and TMS measures of cortical inhibition 
      and excitability in children and adolescents. METHODS: Twenty-four depressed and 
      22 healthy control youth underwent TMS testing (cortical silent period [CSP], 
      short-interval intracortical inhibition at 2-ms and 4-ms interstimulus intervals 
      (ISIs) [SICI-2,-4], resting motor threshold [RMT] and intracortical facilitation 
      at 10-, 15-, and 20-ms ISIs [ICF-10,-15,-20]). Symptom severity was assessed with 
      the Quick Inventory of Depressive Symptomatology (QIDS-A17-SR) and the Children's 
      Depression Rating Scale-Revised (CDRS-R). RESULTS: In the overall sample, the 
      following significant negative correlations were observed: CDRS-R and CSP (right 
      hemisphere, rho=-0.35, p=0.021); QIDS-A17-SR and CSP (left, rho=-0.33, p=0.031; 
      right, rho=-0.42, p=0.004); and CDRS-R and SICI-4 (right, rho=-0.30, p=0.042). Among 
      healthy control participants, additional significant negative correlations were 
      observed between QIDS-A17-SR and right ICF-10; QIDS-A17-SR and right ICF-15; and 
      QIDS-A17-SR and left ICF-20. Among depressed participants, significant negative 
      correlations were observed between QIDS-A17-SR and bilateral CSP; CDRS-R and 
      bilateral ICF-10; CDRS-R and bilateral ICF-15; QIDS-A17-SR and left ICF-10; and 
      QIDS-A17-SR and bilateral ICF-15. LIMITATIONS: Small sample, potential 
      developmental/age- and sex-related effects. CONCLUSIONS: These preliminary 
      results provide evidence for a relationship between depression severity and 
      dysfunction in GABAergic and glutamatergic cortical processes in a pediatric 
      population.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Lewis, Charles P
AU  - Lewis CP
AD  - Department of Psychiatry and Psychology, Division of Child and Adolescent 
      Psychiatry, Mayo Clinic, Rochester, MN, USA. Electronic address: 
      Lewis.Charles@mayo.edu.
FAU - Nakonezny, Paul A
AU  - Nakonezny PA
AD  - Department of Psychiatry, University of Texas Southwestern Medical Center, 
      Dallas, TX, USA; Department of Clinical Sciences, Division of Biostatistics, 
      University of Texas Southwestern Medical Center, Dallas, TX, USA.
FAU - Ameis, Stephanie H
AU  - Ameis SH
AD  - Temerty Centre for Therapeutic Brain Intervention, Campbell Family Mental Health 
      Research Institute, Centre for Addiction and Mental Health, University of 
      Toronto, Toronto, Ontario, Canada.
FAU - Vande Voort, Jennifer L
AU  - Vande Voort JL
AD  - Department of Psychiatry and Psychology, Division of Child and Adolescent 
      Psychiatry, Mayo Clinic, Rochester, MN, USA.
FAU - Husain, Mustafa M
AU  - Husain MM
AD  - Department of Psychiatry, University of Texas Southwestern Medical Center, 
      Dallas, TX, USA; Department of Neurology and Neurotherapeutics, University of 
      Texas Southwestern Medical Center, Dallas, TX, USA.
FAU - Emslie, Graham J
AU  - Emslie GJ
AD  - Department of Psychiatry, University of Texas Southwestern Medical Center, 
      Dallas, TX, USA; Department of Pediatrics, University of Texas Southwestern 
      Medical Center, Dallas, TX, USA; Children's Medical Center of Dallas, Dallas, TX, 
      USA.
FAU - Daskalakis, Zafiris J
AU  - Daskalakis ZJ
AD  - Temerty Centre for Therapeutic Brain Intervention, Campbell Family Mental Health 
      Research Institute, Centre for Addiction and Mental Health, University of 
      Toronto, Toronto, Ontario, Canada.
FAU - Croarkin, Paul E
AU  - Croarkin PE
AD  - Department of Psychiatry and Psychology, Division of Child and Adolescent 
      Psychiatry, Mayo Clinic, Rochester, MN, USA.
LA  - eng
GR  - K23 MH100266/MH/NIMH NIH HHS/United States
GR  - K23MH100266/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151028
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Depression/diagnosis/*physiopathology
MH  - Electromyography
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiopathology
MH  - Neural Inhibition/*physiology
MH  - Transcranial Magnetic Stimulation
PMC - PMC4685002
MID - NIHMS739642
OTO - NOTNLM
OT  - Child and adolescent depression
OT  - Cortical inhibition
OT  - GABA
OT  - Glutamate
OT  - Intracortical facilitation
OT  - Transcranial magnetic stimulation
EDAT- 2015/11/19 06:00
MHDA- 2016/08/10 06:00
PMCR- 2017/01/15
CRDT- 2015/11/19 06:00
PHST- 2015/08/20 00:00 [received]
PHST- 2015/10/01 00:00 [revised]
PHST- 2015/10/15 00:00 [accepted]
PHST- 2015/11/19 06:00 [entrez]
PHST- 2015/11/19 06:00 [pubmed]
PHST- 2016/08/10 06:00 [medline]
PHST- 2017/01/15 00:00 [pmc-release]
AID - S0165-0327(15)30816-8 [pii]
AID - 10.1016/j.jad.2015.10.020 [doi]
PST - ppublish
SO  - J Affect Disord. 2016 Jan 15;190:566-575. doi: 10.1016/j.jad.2015.10.020. Epub 
      2015 Oct 28.