PMID- 26581623
OWN - NLM
STAT- MEDLINE
DCOM- 20161010
LR  - 20161230
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 80
IP  - 1
DP  - 2016
TI  - Prognostic Factors for Survival in Pulmonary Hypertension Due to Left Heart 
      Disease.
PG  - 243-9
LID - 10.1253/circj.CJ-15-0708 [doi]
AB  - BACKGROUND: The epidemiological data of pulmonary hypertension (PH) due to left 
      heart disease (LHD) are limited. This study investigated hemodynamic and clinical 
      factors associated with mortality in patients with PH due to LHD. METHODS AND 
      RESULTS: We conducted a retrospective review in 243 patients with PH due to LHD, 
      defined as mean pulmonary arterial pressure >/=25 mmHg and pulmonary wedge pressure 
      >15 mmHg at rest in right heart catheterization. Kaplan-Meier and Cox 
      proportional hazard regression analyses were performed. Seventy-five patients 
      died during an average follow-up of 52 months (range, 20-73 months). On 
      multivariate analysis, only diastolic pulmonary vascular pressure gradient (DPG) 
      >/=7 mmHg among hemodynamic measurements was a predictor of mortality. Elevated 
      N-terminal pro-brain natriuretic peptide (NT-pro BNP), more severe New York Heart 
      Association (NYHA) class, anemia, and renal dysfunction were more strongly 
      associated with mortality. Mean right atrial pressure (RAP) and currently 
      available markers of pulmonary vascular remodeling including transpulmonary 
      pressure gradient (TPG) and pulmonary vascular resistance (PVR) had no effect on 
      survival. CONCLUSIONS: DPG is weakly associated with mortality in PH due to LHD. 
      Clinical factors such as NT-pro BNP, NYHA class, anemia and renal dysfunction are 
      superior predictors. The prognostic ability of hemodynamic factors such as mean 
      RAP, TPG, PVR and DPG is limited.
FAU - Yamabe, Sayuri
AU  - Yamabe S
AD  - Department of Cardiovascular Medicine, Hiroshima University Graduate School of 
      Biomedical and Health Sciences.
FAU - Dohi, Yoshihiro
AU  - Dohi Y
FAU - Fujisaki, Shinya
AU  - Fujisaki S
FAU - Higashi, Akifumi
AU  - Higashi A
FAU - Kinoshita, Hiroki
AU  - Kinoshita H
FAU - Sada, Yoshiharu
AU  - Sada Y
FAU - Hidaka, Takayuki
AU  - Hidaka T
FAU - Kurisu, Satoshi
AU  - Kurisu S
FAU - Yamamoto, Hideya
AU  - Yamamoto H
FAU - Kihara, Yasuki
AU  - Kihara Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151117
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
CIN - Circ J. 2016;80(1):72-3. PMID: 26658283
MH  - Aged
MH  - *Blood Pressure
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Diseases/blood/complications/physiopathology
MH  - Humans
MH  - *Hypertension, Pulmonary/blood/complications/mortality/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Retrospective Studies
MH  - Survival Rate
MH  - *Vascular Remodeling
EDAT- 2015/11/20 06:00
MHDA- 2016/10/11 06:00
CRDT- 2015/11/20 06:00
PHST- 2015/11/20 06:00 [entrez]
PHST- 2015/11/20 06:00 [pubmed]
PHST- 2016/10/11 06:00 [medline]
AID - 10.1253/circj.CJ-15-0708 [doi]
PST - ppublish
SO  - Circ J. 2016;80(1):243-9. doi: 10.1253/circj.CJ-15-0708. Epub 2015 Nov 17.