PMID- 26584027
OWN - NLM
STAT- MEDLINE
DCOM- 20160714
LR  - 20181202
IS  - 1662-4033 (Electronic)
IS  - 1662-4025 (Print)
IS  - 1662-4025 (Linking)
VI  - 8
IP  - 6
DP  - 2015
TI  - Metabolic Mechanisms in Obesity and Type 2 Diabetes: Insights from 
      Bariatric/Metabolic Surgery.
PG  - 350-63
LID - 10.1159/000441259 [doi]
AB  - Obesity and the related diabetes epidemics represent a real concern worldwide. 
      Bariatric/metabolic surgery emerged in last years as a valuable therapeutic 
      option for obesity and related diseases, including type 2 diabetes mellitus 
      (T2DM). The complicated network of mechanisms involved in obesity and T2DM have 
      not completely defined yet. There is still a debate on which would be the first 
      metabolic defect leading to metabolic deterioration: insulin resistance or 
      hyperinsulinemia? Insight into the metabolic effects of bariatric/metabolic 
      surgery has revealed that, beyond weight loss and food restriction, other 
      mechanisms can be activated by the rearrangements of the gastrointestinal tract, 
      such as the incretinic/anti-incretinic system, changes in bile acid composition 
      and flow, and modifications of gut microbiota; all of them possibly involved in 
      the remission of T2DM. The complete elucidation of these mechanisms will lead to 
      a better understanding of the pathogenesis of this disease. Our aim was to review 
      some of the metabolic mechanisms involved in the development of T2DM in obese 
      patients as well as in the remission of this condition in patients submitted to 
      bariatric/metabolic surgery.
CI  - (c) 2015 S. Karger GmbH, Freiburg.
FAU - Catoi, Adriana Florinela
AU  - Catoi AF
AD  - Department of Functional Biosciences, Faculty of Medicine, x2018;Iuliu 
      Hax0163;ieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
FAU - Parvu, Alina
AU  - Parvu A
FAU - Muresan, Adriana
AU  - Muresan A
FAU - Busetto, Luca
AU  - Busetto L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151120
PL  - Switzerland
TA  - Obes Facts
JT  - Obesity facts
JID - 101469429
RN  - 0 (Insulin)
SB  - IM
MH  - *Bariatric Surgery
MH  - *Diabetes Mellitus, Type 2/etiology/metabolism/surgery
MH  - *Gastrointestinal Tract/microbiology
MH  - Humans
MH  - Hyperinsulinism/metabolism
MH  - Insulin/*metabolism
MH  - Insulin Resistance
MH  - *Obesity/complications/metabolism/surgery
PMC - PMC5644813
EDAT- 2015/11/20 06:00
MHDA- 2016/07/15 06:00
PMCR- 2015/11/20
CRDT- 2015/11/20 06:00
PHST- 2015/06/29 00:00 [received]
PHST- 2015/09/17 00:00 [accepted]
PHST- 2015/11/20 06:00 [entrez]
PHST- 2015/11/20 06:00 [pubmed]
PHST- 2016/07/15 06:00 [medline]
PHST- 2015/11/20 00:00 [pmc-release]
AID - 000441259 [pii]
AID - ofa-0008-0350 [pii]
AID - 10.1159/000441259 [doi]
PST - ppublish
SO  - Obes Facts. 2015;8(6):350-63. doi: 10.1159/000441259. Epub 2015 Nov 20.