PMID- 26584702
OWN - NLM
STAT- MEDLINE
DCOM- 20160909
LR  - 20151120
IS  - 1525-1470 (Electronic)
IS  - 0736-8046 (Linking)
VI  - 32
IP  - 6
DP  - 2015 Nov-Dec
TI  - Febrile Ulceronecrotic Mucha-Habermann Disease: Two Cases with Excellent Response 
      to Methotrexate.
PG  - e307-8
LID - 10.1111/pde.12687 [doi]
AB  - Febrile ulceronecrotic Mucha-Habermann disease (FUMHD), a severe form of 
      pityriasis lichenoides et varioliformis acuta (PLEVA), featuring large, 
      ulcerative, necrotic skin plaques, high fever, and other systemic symptoms, is a 
      rare disorder of unknown etiology. No randomized controlled trials have 
      established treatment guidelines and multiple modalities are often employed, 
      making it difficult to assess the efficacy of any single agent. We report two 
      cases of this condition in which treatment with methotrexate plus antibiotic 
      treatment for superinfection led to rapid improvement.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Griffith-Bauer, Kelly
AU  - Griffith-Bauer K
AD  - Department of Dermatology, Center for Health and Healing, Oregon Health and 
      Science University, Portland, Oregon.
FAU - Leitenberger, Sabra L
AU  - Leitenberger SL
AD  - Department of Dermatology, Center for Health and Healing, Oregon Health and 
      Science University, Portland, Oregon.
FAU - Krol, Alfons
AU  - Krol A
AD  - Department of Dermatology, Center for Health and Healing, Oregon Health and 
      Science University, Portland, Oregon.
LA  - eng
PT  - Journal Article
DEP - 20151008
PL  - United States
TA  - Pediatr Dermatol
JT  - Pediatric dermatology
JID - 8406799
RN  - OBN7UDS42Y (Cephalexin)
RN  - YL5FZ2Y5U1 (Methotrexate)
RN  - Febrile Ulceronecrotic Mucha-Habermann disease
SB  - IM
MH  - Biopsy, Needle
MH  - Cephalexin/administration & dosage
MH  - Child
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Drug Therapy, Combination
MH  - Exanthema/diagnosis/etiology
MH  - Fever/diagnosis/etiology
MH  - Follow-Up Studies
MH  - Herpes Simplex/*diagnosis/*drug therapy
MH  - Hospitalization
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Methotrexate/*administration & dosage
MH  - Pityriasis Lichenoides/*diagnosis/*drug therapy
MH  - Rare Diseases
MH  - Risk Assessment
MH  - Sampling Studies
MH  - Severity of Illness Index
MH  - Superinfection/drug therapy/*prevention & control
MH  - Treatment Outcome
EDAT- 2015/11/21 06:00
MHDA- 2016/09/10 06:00
CRDT- 2015/11/21 06:00
PHST- 2015/11/21 06:00 [entrez]
PHST- 2015/11/21 06:00 [pubmed]
PHST- 2016/09/10 06:00 [medline]
AID - 10.1111/pde.12687 [doi]
PST - ppublish
SO  - Pediatr Dermatol. 2015 Nov-Dec;32(6):e307-8. doi: 10.1111/pde.12687. Epub 2015 
      Oct 8.