PMID- 26585372 OWN - NLM STAT- MEDLINE DCOM- 20161011 LR - 20181113 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 5 DP - 2015 Nov 20 TI - White matter structures associated with loneliness in young adults. PG - 17001 LID - 10.1038/srep17001 [doi] LID - 17001 AB - Lonely individuals may exhibit dysfunction, particularly with respect to social empathy and self-efficacy. White matter (WM) structures related to loneliness have not yet been identified. We investigated the association between regional WM density (rWMD) using the UCLA Loneliness Scale in 776 healthy young students aged 18-27 years old. Loneliness scores were negatively correlated with rWMD in eight clusters: the bilateral inferior parietal lobule (IPL), right anterior insula (AI), posterior temporoparietal junction (pTPJ), left posterior superior temporal sulcus (pSTS), dorsomedial prefrontal cortex (dmPFC), and rostrolateral prefrontal cortex (RLPFC). The bilateral IPL, right AI, left pSTS, pTPJ, and RLPFC were strongly associated with Empathy Quotient (EQ), whereas the bilateral IPL, right AI, left pTPJ, and dmPFC were associated with General Self-Efficacy Scale (GSES) score. The neural correlates of loneliness comprise widespread reduction in WMD in areas related to self- and social cognition as well as areas associated with empathy and self-efficacy. FAU - Nakagawa, Seishu AU - Nakagawa S AD - Department of Psychiatry, Tohoku Pharmaceutical University, Sendai, Japan. AD - Department of Functional Brain Imaging, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Takeuchi, Hikaru AU - Takeuchi H AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Taki, Yasuyuki AU - Taki Y AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. AD - Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. AD - Department of Nuclear Medicine and Radiology, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Nouchi, Rui AU - Nouchi R AD - Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan. AD - Smart Ageing International Research Center, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Sekiguchi, Atsushi AU - Sekiguchi A AD - Department of Functional Brain Imaging, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. AD - Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. AD - Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. FAU - Kotozaki, Yuka AU - Kotozaki Y AD - Smart Ageing International Research Center, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Miyauchi, Carlos Makoto AU - Miyauchi CM AD - Department of Functional Brain Imaging, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. AD - Graduate School of Arts and Sciences, Department of General Systems Studies, The University of Tokyo. FAU - Iizuka, Kunio AU - Iizuka K AD - Department of Functional Brain Imaging, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. AD - Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan. FAU - Yokoyama, Ryoichi AU - Yokoyama R AD - Department of Functional Brain Imaging, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. AD - Japan Society for the Promotion of Science, Tokyo, Japan. FAU - Shinada, Takamitsu AU - Shinada T AD - Department of Functional Brain Imaging, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Yamamoto, Yuki AU - Yamamoto Y AD - Department of Functional Brain Imaging, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Hanawa, Sugiko AU - Hanawa S AD - Department of Functional Brain Imaging, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Araki, Tsuyoshi AU - Araki T AD - Smart Ageing International Research Center, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Hashizume, Hiroshi AU - Hashizume H AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Kunitoki, Keiko AU - Kunitoki K AD - Faculty of Medicine, Tohoku University, Sendai, Japan. FAU - Sassa, Yuko AU - Sassa Y AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. FAU - Kawashima, Ryuta AU - Kawashima R AD - Department of Functional Brain Imaging, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. AD - Smart Ageing International Research Center, Institute of Development, Ageing and Cancer, Tohoku University, Sendai, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151120 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adolescent MH - Adult MH - Analysis of Variance MH - Brain Mapping MH - Empathy/*physiology MH - Female MH - Humans MH - Loneliness/*psychology MH - Magnetic Resonance Imaging MH - Male MH - Models, Neurological MH - Models, Psychological MH - Prefrontal Cortex/anatomy & histology/physiology MH - *Self Efficacy MH - Social Behavior MH - White Matter/anatomy & histology/*physiology MH - Young Adult PMC - PMC4653806 EDAT- 2015/11/21 06:00 MHDA- 2016/10/12 06:00 PMCR- 2015/11/20 CRDT- 2015/11/21 06:00 PHST- 2015/05/10 00:00 [received] PHST- 2015/10/22 00:00 [accepted] PHST- 2015/11/21 06:00 [entrez] PHST- 2015/11/21 06:00 [pubmed] PHST- 2016/10/12 06:00 [medline] PHST- 2015/11/20 00:00 [pmc-release] AID - srep17001 [pii] AID - 10.1038/srep17001 [doi] PST - epublish SO - Sci Rep. 2015 Nov 20;5:17001. doi: 10.1038/srep17001.