PMID- 26586273
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Nov 20
TI  - A Wireless Intracranial Brain Deformation Sensing System for Blast-Induced 
      Traumatic Brain Injury.
PG  - 16959
LID - 10.1038/srep16959 [doi]
LID - 16959
AB  - Blast-induced traumatic brain injury (bTBI) has been linked to a multitude of 
      delayed-onset neurodegenerative and neuropsychiatric disorders, but complete 
      understanding of their pathogenesis remains elusive. To develop mechanistic 
      relationships between bTBI and post-blast neurological sequelae, it is imperative 
      to characterize the initiating traumatic mechanical events leading to eventual 
      alterations of cell, tissue, and organ structure and function. This paper 
      presents a wireless sensing system capable of monitoring the intracranial brain 
      deformation in real-time during the event of a bTBI. The system consists of an 
      implantable soft magnet and an external head-mounted magnetic sensor that is able 
      to measure the field in three dimensions. The change in the relative position of 
      the soft magnet WITH respect to the external sensor as the result of the blast 
      wave induces changes in the magnetic field. The magnetic field data in turn is 
      used to extract the temporal and spatial motion of the brain under the blast wave 
      in real-time. The system has temporal and spatial resolutions of 5 mus and 10 mum. 
      Following the characterization and validation of the sensor system, we measured 
      brain deformations in a live rodent during a bTBI.
FAU - Song, S
AU  - Song S
AD  - School of Electrical and Computer Engineering, Purdue University, West Lafayette, 
      IN, USA.
AD  - Birck Nanotechnology Center, West Lafayette, IN, USA.
FAU - Race, N S
AU  - Race NS
AD  - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 
      USA.
AD  - School of Medicine, Indiana University, Indianapolis, IN, USA.
FAU - Kim, A
AU  - Kim A
AD  - School of Electrical and Computer Engineering, Purdue University, West Lafayette, 
      IN, USA.
AD  - Birck Nanotechnology Center, West Lafayette, IN, USA.
FAU - Zhang, T
AU  - Zhang T
AD  - School of Electrical and Computer Engineering, Purdue University, West Lafayette, 
      IN, USA.
AD  - Birck Nanotechnology Center, West Lafayette, IN, USA.
FAU - Shi, R
AU  - Shi R
AD  - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 
      USA.
AD  - Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA.
FAU - Ziaie, B
AU  - Ziaie B
AD  - School of Electrical and Computer Engineering, Purdue University, West Lafayette, 
      IN, USA.
AD  - Birck Nanotechnology Center, West Lafayette, IN, USA.
LA  - eng
GR  - R21 NS090244/NS/NINDS NIH HHS/United States
GR  - 1 R21 NS090244-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151120
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Ferric Compounds)
RN  - 0 (Silicone Elastomers)
RN  - 1K09F3G675 (ferric oxide)
SB  - IM
MH  - Animals
MH  - Biosensing Techniques/instrumentation/*methods
MH  - Blast Injuries/*complications
MH  - Brain Diseases/*diagnosis/physiopathology
MH  - Brain Injuries/*diagnosis/etiology/physiopathology
MH  - Ferric Compounds/chemistry
MH  - Humans
MH  - Magnetic Fields
MH  - Magnets/chemistry
MH  - Motion
MH  - Nanoparticles/chemistry
MH  - Rats
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Silicone Elastomers/chemistry
MH  - *Wireless Technology
PMC - PMC4653713
EDAT- 2015/11/21 06:00
MHDA- 2016/10/12 06:00
PMCR- 2015/11/20
CRDT- 2015/11/21 06:00
PHST- 2015/05/28 00:00 [received]
PHST- 2015/10/20 00:00 [accepted]
PHST- 2015/11/21 06:00 [entrez]
PHST- 2015/11/21 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
PHST- 2015/11/20 00:00 [pmc-release]
AID - srep16959 [pii]
AID - 10.1038/srep16959 [doi]
PST - epublish
SO  - Sci Rep. 2015 Nov 20;5:16959. doi: 10.1038/srep16959.