PMID- 26586462
OWN - NLM
STAT- MEDLINE
DCOM- 20161222
LR  - 20181113
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 103
IP  - 1
DP  - 2016 Jan
TI  - Intrathecal donor lymphocyte infusion for isolated leukemia relapse in the 
      central nervous system following allogeneic stem cell transplantation: a case 
      report and literature review.
PG  - 107-11
LID - 10.1007/s12185-015-1902-1 [doi]
AB  - An 8-year-old boy with a bone marrow relapse of T cell acute lymphoblastic 
      leukemia underwent stem-cell transplantation from a human leukocyte antigen 
      (HLA)-haploidentical mother. Five months later, he relapsed with central nervous 
      system (CNS) involvement. Systemic chemotherapy and repeated intrathecal 
      chemotherapy induced consciousness disturbances and frequent arrhythmia, 
      prompting us to discontinue the chemotherapy. He had already received an 18-Gy 
      prophylactic cranial irradiation, an 8-Gy total body irradiation, and a 15-Gy 
      local irradiation for pituitary gland involvement. We therefore performed five 
      intrathecal donor lymphocyte infusions (IDLIs) in escalating doses from 1 x 10(4) 
      up to 1 x 10(6) cells/kg. All IDLIs were safe without infusion reactions or 
      graft-versus-host disease. After the second and later IDLIs, donor mononuclear 
      cells were continuously detected in cerebrospinal fluid; however, he did not 
      achieve donor-dominant chimerism. Based on our case and four cases reported in 
      the literature, the efficacy of IDLI therapy is limited for CNS relapse of 
      hematological malignancies. However, we suggest that IDLI remains a feasible and 
      safe option, as no GVHD or other adverse effects occurred, even in the 
      HLA-haploidentical setting. We will make further efforts to increase the 
      efficacy.
FAU - Yanagisawa, Ryu
AU  - Yanagisawa R
AD  - Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto, 390-8621, Japan.
AD  - Division of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan.
FAU - Nakazawa, Yozo
AU  - Nakazawa Y
AD  - Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto, 390-8621, Japan. yxnakaza@shinshu-u.ac.jp.
FAU - Sakashita, Kazuo
AU  - Sakashita K
AD  - Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto, 390-8621, Japan.
AD  - Division of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan.
FAU - Saito, Shoji
AU  - Saito S
AD  - Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto, 390-8621, Japan.
FAU - Tanaka, Miyuki
AU  - Tanaka M
AD  - Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto, 390-8621, Japan.
FAU - Shiohara, Masaaki
AU  - Shiohara M
AD  - Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto, 390-8621, Japan.
AD  - Department of Pediatrics, School of Dentistry, Matsumoto Dental University, 
      Shiojiri, Japan.
FAU - Shimodaira, Shigetaka
AU  - Shimodaira S
AD  - Division of Blood Transfusion, Shinshu University Hospital, Matsumoto, Japan.
AD  - Center for Advanced Cell Therapy, Shinshu University Hospital, Matsumoto, Japan.
FAU - Koike, Kenichi
AU  - Koike K
AD  - Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, 
      Matsumoto, 390-8621, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20151119
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Allografts
MH  - Bone Marrow
MH  - Central Nervous System Neoplasms/*therapy
MH  - Child
MH  - Female
MH  - HLA Antigens
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility
MH  - Humans
MH  - Injections, Spinal
MH  - Lymphocyte Transfusion/*methods
MH  - Male
MH  - Neoplasm Recurrence, Local
MH  - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*therapy
MH  - Tissue Donors
OTO - NOTNLM
OT  - Acute lymphoblastic leukemia
OT  - CNS relapse
OT  - Donor lymphocyte infusion
OT  - Stem cell transplantation
EDAT- 2015/11/21 06:00
MHDA- 2016/12/23 06:00
CRDT- 2015/11/21 06:00
PHST- 2015/08/03 00:00 [received]
PHST- 2015/11/09 00:00 [accepted]
PHST- 2015/11/04 00:00 [revised]
PHST- 2015/11/21 06:00 [entrez]
PHST- 2015/11/21 06:00 [pubmed]
PHST- 2016/12/23 06:00 [medline]
AID - 10.1007/s12185-015-1902-1 [pii]
AID - 10.1007/s12185-015-1902-1 [doi]
PST - ppublish
SO  - Int J Hematol. 2016 Jan;103(1):107-11. doi: 10.1007/s12185-015-1902-1. Epub 2015 
      Nov 19.