PMID- 26586912
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20161230
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 120
IP  - 2
DP  - 2016 Jan 15
TI  - Altering fatty acid availability does not impair prolonged, continuous running to 
      fatigue: evidence for carbohydrate dependence.
PG  - 107-13
LID - 10.1152/japplphysiol.00855.2015 [doi]
AB  - We determined the effect of suppressing lipolysis via administration of nicotinic 
      acid (NA) on fuel substrate selection and half-marathon running capacity. In a 
      single-blinded, Latin square design, 12 competitive runners completed four trials 
      involving treadmill running until volitional fatigue at a pace based on 95% of 
      personal best half-marathon time. Trials were completed in a fed or overnight 
      fasted state: 1) carbohydrate (CHO) ingestion before (2 g CHO.kg(-1).body 
      mass(-1)) and during (44 g/h) [CFED]; 2) CFED plus NA ingestion [CFED-NA]; 3) 
      fasted with placebo ingestion during [FAST]; and 4) FAST plus NA ingestion 
      [FAST-NA]. There was no difference in running distance (CFED, 21.53 +/- 1.07; 
      CFED-NA, 21.29 +/- 1.69; FAST, 20.60 +/- 2.09; FAST-NA, 20.11 +/- 1.71 km) or time to 
      fatigue between the four trials. Concentrations of plasma free fatty acids (FFA) 
      and glycerol were suppressed following NA ingestion irrespective of preexercise 
      nutritional intake but were higher throughout exercise in FAST compared with all 
      other trials (P < 0.05). Rates of whole-body CHO oxidation were unaffected by NA 
      ingestion in the CFED and FAST trials, but were lower in the FAST trial compared 
      with the CFED-NA trial (P < 0.05). CHO was the primary substrate for exercise in 
      all conditions, contributing 83-91% to total energy expenditure with only a small 
      contribution from fat-based fuels. Blunting the exercise-induced increase in FFA 
      via NA ingestion did not impair intense running capacity lasting  approximately 85 min, nor did 
      it alter patterns of substrate oxidation in competitive athletes. Although there 
      was a small but obligatory use of fat-based fuels, the oxidation of CHO-based 
      fuels predominates during half-marathon running.
CI  - Copyright (c) 2016 the American Physiological Society.
FAU - Leckey, Jill J
AU  - Leckey JJ
AD  - Centre for Exercise and Nutrition, Mary MacKillop Institute for Health Research, 
      Australian Catholic University, Melbourne, Australia;
FAU - Burke, Louise M
AU  - Burke LM
AD  - Sports Nutrition, Australian Institute of Sport, Canberra, Australia; and.
FAU - Morton, James P
AU  - Morton JP
AD  - Research Institute for Sport and Exercise Sciences, Liverpool John Moores 
      University, Liverpool, United Kingdom.
FAU - Hawley, John A
AU  - Hawley JA
AD  - Centre for Exercise and Nutrition, Mary MacKillop Institute for Health Research, 
      Australian Catholic University, Melbourne, Australia; Research Institute for 
      Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United 
      Kingdom john.hawley@acu.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151119
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Adult
MH  - Dietary Carbohydrates/*metabolism
MH  - Energy Metabolism/*physiology
MH  - Exercise/physiology
MH  - Fatigue/*blood/metabolism/*physiopathology
MH  - Fatty Acids, Nonesterified/*blood
MH  - Glycerol/metabolism
MH  - Humans
MH  - Lipolysis/physiology
MH  - Male
MH  - Oxidation-Reduction
MH  - Running/*physiology
MH  - Single-Blind Method
OTO - NOTNLM
OT  - carbohydrate
OT  - high-intensity running
OT  - nicotinic acid
OT  - performance
OT  - substrate utilization
EDAT- 2015/11/21 06:00
MHDA- 2016/10/12 06:00
CRDT- 2015/11/21 06:00
PHST- 2015/10/07 00:00 [received]
PHST- 2015/11/13 00:00 [accepted]
PHST- 2015/11/21 06:00 [entrez]
PHST- 2015/11/21 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
AID - japplphysiol.00855.2015 [pii]
AID - 10.1152/japplphysiol.00855.2015 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2016 Jan 15;120(2):107-13. doi: 
      10.1152/japplphysiol.00855.2015. Epub 2015 Nov 19.