PMID- 26587885
OWN - NLM
STAT- MEDLINE
DCOM- 20161025
LR  - 20191210
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 7
IP  - 51
DP  - 2015 Dec 30
TI  - Reactive Oxygen Species-Manipulated Drug Release from a Smart Envelope-Type 
      Mesoporous Titanium Nanovehicle for Tumor Sonodynamic-Chemotherapy.
PG  - 28554-65
LID - 10.1021/acsami.5b09937 [doi]
AB  - Despite advances in drug delivery systems (DDSs), the stimuli-responsive 
      controlled release DDSs with high spatial/temporal resolution are still the best 
      choice. Herein, a novel type of envelope-type mesoporous titanium dioxide 
      nanoparticle (MTN) was developed for one-demand drug delivery platform. Docetaxel 
      (DTX) was loaded in the pores of MTN with a high drug loading efficiency ( approximately 26%). 
      Then beta-cyclodextrin (beta-CD, a bulky gatekeeper) was attached to the outer surface 
      of MTN via a reactive oxygen species (ROS) sensitive linker to block the pores 
      (MTN@DTX-CD). MTN@DTX-CD could entrap the DTX in the pores and allow the rapid 
      release until a focused ultrasound (US) emerged. A large number of ROS were 
      generated by MTN under US radiation, leading to the cleavage of the ROS-sensitive 
      linker; thus, DTX could be released rapidly since the gatekeepers (beta-CD) were 
      detached. Besides, the generation of ROS could also be used for tumor-specific 
      sonodynamic therapy (SDT). Studies have shown the feasibility of MTN@DTX-CD for 
      US-triggered DTX release and sonodynamic-chemotherapy. In the in vitro and in 
      vivo studies, by integrating SDT and chemotherapy into one system, MTN@DTX-CD 
      showed excellent antitumor efficacy. More importantly, this novel DDS 
      significantly decreased the side effects of DTX by avoiding the spleen and 
      hematologic toxicity to tumor-bearing mice.
FAU - Shi, Jinjin
AU  - Shi J
AD  - School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou 450001, P.R. 
      China.
AD  - Collaborative Innovation Center of New Drug Research, Safety Evaluation, Henan 
      Province, Zhengzhou 450001, P.R. China.
FAU - Chen, Zhaoyang
AU  - Chen Z
AD  - School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou 450001, P.R. 
      China.
FAU - Wang, Binghua
AU  - Wang B
AD  - School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou 450001, P.R. 
      China.
FAU - Wang, Lei
AU  - Wang L
AD  - School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou 450001, P.R. 
      China.
FAU - Lu, Tingting
AU  - Lu T
AD  - School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou 450001, P.R. 
      China.
FAU - Zhang, Zhenzhong
AU  - Zhang Z
AD  - School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou 450001, P.R. 
      China.
AD  - Collaborative Innovation Center of New Drug Research, Safety Evaluation, Henan 
      Province, Zhengzhou 450001, P.R. China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151221
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Taxoids)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 15H5577CQD (Docetaxel)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage/chemistry
MH  - Cell Line, Tumor
MH  - Docetaxel
MH  - Drug Carriers/*chemistry
MH  - Drug Delivery Systems/instrumentation/*methods
MH  - Female
MH  - Humans
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neoplasms/*drug therapy/*metabolism
MH  - Reactive Oxygen Species/*metabolism
MH  - Taxoids/administration & dosage/chemistry
MH  - Titanium/chemistry
OTO - NOTNLM
OT  - ROS-manipulated drug release
OT  - combination therapy
OT  - mesoporous titanium dioxide nanoparticle
OT  - nanomedicine
OT  - sonodynamic therapy
EDAT- 2015/11/21 06:00
MHDA- 2016/10/26 06:00
CRDT- 2015/11/21 06:00
PHST- 2015/11/21 06:00 [entrez]
PHST- 2015/11/21 06:00 [pubmed]
PHST- 2016/10/26 06:00 [medline]
AID - 10.1021/acsami.5b09937 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2015 Dec 30;7(51):28554-65. doi: 
      10.1021/acsami.5b09937. Epub 2015 Dec 21.