PMID- 26588579
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20161230
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 136
IP  - 2
DP  - 2016
TI  - A correlation analysis between HDAC1 over-expression and clinical features of 
      laryngeal squamous cell carcinoma.
PG  - 172-6
LID - 10.3109/00016489.2015.1101781 [doi]
AB  - CONCLUSION: HDAC1 may be a prognostic biomarker for LSCC malignant potency and a 
      potent factor resulting in decreased sensitivity of LSCC in radiotherapy. 
      OBJECTIVE: The aim of this study was to evaluate the correlation between histone 
      deacetylase 1 (HDAC1) over-expression and clinical features in laryngeal squamous 
      cell carcinoma (LSCC). METHODS: This study assessed the HDAC1 expressions in 90 
      formalin-fixed paraffin-embedded LSCC samples, 30 adjacent non-neoplastic 
      tissues, and 30 laryngeal polyp tissues by immunohistochemistry (IHC). In 
      addition, another 40 LSCC samples were collected that were divided into two 
      groups after 3-month radiotherapy: the high radio-sensitive group (HRS) and low 
      radio-sensitive group (LRS). Overall survival curves of all the LSCC patients 
      were constructed by Kaplan-Meier method and long-rank test. RESULTS: All ninety 
      samples were positively immunostained for HDAC1. The expression of HDAC1 was 
      up-regulated and significantly associated with T classification, lymph node 
      metastases, tumor location and clinical stage. HDAC1 was mainly labeled in the 
      epithelial cells of laryngeal polyp tissues and adjacent non-neoplastic tissues. 
      In addition, the expression of HDAC1 was significantly higher in LRS than that in 
      HRS. The positive rates for stage III-IV tumor were significantly higher than 
      those for stage II. LSCC patients with HDAC1 over-expression and LRS presented a 
      shorter 5-year overall survival rate.
FAU - Zhao, Rui
AU  - Zhao R
AD  - a Department of Otorhinolaryngology, Head and Neck Surgery , The Second 
      Affiliated Hospital of Harbin Medical University , Harbin , PR China.
FAU - Chen, Kexin
AU  - Chen K
AD  - a Department of Otorhinolaryngology, Head and Neck Surgery , The Second 
      Affiliated Hospital of Harbin Medical University , Harbin , PR China.
FAU - Cao, Jing
AU  - Cao J
AD  - a Department of Otorhinolaryngology, Head and Neck Surgery , The Second 
      Affiliated Hospital of Harbin Medical University , Harbin , PR China.
FAU - Yu, Hao
AU  - Yu H
AD  - a Department of Otorhinolaryngology, Head and Neck Surgery , The Second 
      Affiliated Hospital of Harbin Medical University , Harbin , PR China.
FAU - Tian, Linli
AU  - Tian L
AD  - a Department of Otorhinolaryngology, Head and Neck Surgery , The Second 
      Affiliated Hospital of Harbin Medical University , Harbin , PR China.
FAU - Liu, Ming
AU  - Liu M
AD  - a Department of Otorhinolaryngology, Head and Neck Surgery , The Second 
      Affiliated Hospital of Harbin Medical University , Harbin , PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151120
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
RN  - EC 3.5.1.98 (HDAC1 protein, human)
RN  - EC 3.5.1.98 (Histone Deacetylase 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/biosynthesis/genetics
MH  - Carcinoma, Squamous Cell/diagnosis/*genetics/metabolism
MH  - DNA, Neoplasm/*genetics
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene Expression Regulation, Neoplastic
MH  - Histone Deacetylase 1/biosynthesis/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/diagnosis/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
OTO - NOTNLM
OT  - HDAC1
OT  - LSCC
OT  - laryngeal polyp
OT  - radio-sensitivity
EDAT- 2015/11/21 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/11/21 06:00
PHST- 2015/11/21 06:00 [entrez]
PHST- 2015/11/21 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - 10.3109/00016489.2015.1101781 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2016;136(2):172-6. doi: 10.3109/00016489.2015.1101781. Epub 
      2015 Nov 20.