PMID- 26588980
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20171102
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 17
IP  - 11
DP  - 2016 Nov
TI  - Sustained favourable haemodynamics 1 year after TAVI: improvement in NYHA 
      functional class related to improvement of left ventricular diastolic function.
PG  - 1269-1278
AB  - AIMS: Despite expected improvement in left ventricular (LV) systolic and 
      diastolic function after transcatheter aortic valve implantation (TAVI), the 
      complex relationship between pre-existent LV systolic and diastolic function and 
      changes in LV haemodynamics and clinical symptoms have been scarcely 
      investigated. This study investigated the presence of pre-operative LV diastolic 
      dysfunction and its improvement over time after TAVI alongside improvement in New 
      York Heart Association (NYHA) class in high-risk patients with severe aortic 
      stenosis. METHODS AND RESULTS: The study population (n = 358) was divided into 
      two groups according to baseline LV ejection fraction (LVEF): LVEF < 50% (n = 96) 
      and LVEF >/= 50% (n = 262). We compared clinical and echocardiographic parameters 
      between groups before TAVI, at 6 and 12 months follow-up. Grade III LV diastolic 
      dysfunction was more frequent in patients with LVEF < 50% compared with patients 
      with LVEF >/= 50% (50.0 vs. 16.3%, P < 0.001). Systolic and diastolic 
      echocardiographic parameters improved after TAVI together with improvement in 
      NYHA class both in patients with LVEF < 50% (diastolic dysfunction grade >/=2: 
      baseline 100% of patients; 12 months 58.8%, P < 0.001; NYHA III/IV: baseline, 
      93.8%; 12 months, 9.7%, P < 0.001) and with LVEF >/= 50% (diastolic dysfunction 
      grade >/=2: baseline, 87.1%; 12 months, 61.2%; NYHA III/IV: baseline, 74.5%; 12 
      months, 2.6%, P < 0.001). All-cause mortality was comparable between groups. 
      CONCLUSION: TAVI exerts favourable effects on LV systolic and diastolic function 
      with a remarkable improvement in LV diastolic function associated with 
      improvement in NYHA functional class at follow-up. Prognosis at 1 year after TAVI 
      was not influenced by baseline LV diastolic dysfunction both in patients with and 
      without LV systolic dysfunction.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author 2015. For permissions please email: journals.permissions@oup.com.
FAU - Muratori, Manuela
AU  - Muratori M
AD  - Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy 
      manuela.muratori@ccfm.it.
FAU - Fusini, Laura
AU  - Fusini L
AD  - Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.
FAU - Tamborini, Gloria
AU  - Tamborini G
AD  - Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.
FAU - Gripari, Paola
AU  - Gripari P
AD  - Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.
FAU - Delgado, Victoria
AU  - Delgado V
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Marsan, Nina Ajmone
AU  - Marsan NA
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Ghulam Ali, Sarah
AU  - Ghulam Ali S
AD  - Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.
FAU - Barbier, Paolo
AU  - Barbier P
AD  - Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.
FAU - Bartorelli, Antonio L
AU  - Bartorelli AL
AD  - Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.
AD  - Department of Clinical Sciences and Community Health, Cardiovascular Section, 
      University of Milan, Milan, Italy.
FAU - Alamanni, Francesco
AU  - Alamanni F
AD  - Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.
AD  - Department of Clinical Sciences and Community Health, Cardiovascular Section, 
      University of Milan, Milan, Italy.
FAU - Pepi, Mauro
AU  - Pepi M
AD  - Centro Cardiologico Monzino IRCCS, Via Parea 4, 20138 Milan, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20151120
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Aortic Valve Stenosis/diagnostic imaging/*mortality/*surgery
MH  - Cohort Studies
MH  - Diastole/physiology
MH  - Echocardiography/methods
MH  - Echocardiography, Doppler, Color/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Stroke Volume/*physiology
MH  - Survival Rate
MH  - Systole/physiology
MH  - Transcatheter Aortic Valve Replacement/*methods/mortality
MH  - Treatment Outcome
MH  - Ventricular Function, Left/physiology
OTO - NOTNLM
OT  - Doppler echocardiography
OT  - diastolic function
OT  - transcatheter aortic valve implantation
EDAT- 2015/11/22 06:00
MHDA- 2017/11/03 06:00
CRDT- 2015/11/22 06:00
PHST- 2015/09/07 00:00 [received]
PHST- 2015/10/22 00:00 [accepted]
PHST- 2015/11/22 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
PHST- 2015/11/22 06:00 [entrez]
AID - jev306 [pii]
AID - 10.1093/ehjci/jev306 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2016 Nov;17(11):1269-1278. doi: 
      10.1093/ehjci/jev306. Epub 2015 Nov 20.