PMID- 26589390
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20181113
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 169
IP  - 1-3
DP  - 2015 Dec
TI  - Patterns of premorbid functioning in individuals at clinical high risk of 
      psychosis.
PG  - 209-213
LID - S0920-9964(15)30047-5 [pii]
LID - 10.1016/j.schres.2015.11.004 [doi]
AB  - In schizophrenia, four typical patterns of premorbid functioning have been 
      observed: stable-good, stable-intermediate, poor-deteriorating and deteriorating. 
      However, it is unknown whether similar patterns exist in those who are at 
      clinical high risk (CHR) of psychosis. The aim of this study was to examine 
      patterns of premorbid functioning in a large sample of individuals at CHR of 
      psychosis and its association with symptoms, functioning, and conversion to 
      psychosis. One-hundred sixty people at CHR of psychosis were assessed on 
      premorbid functioning using the Premorbid Adjustment Scale. Poorer premorbid 
      functioning was significantly correlated with worse negative symptom severity and 
      lower social functioning. Cluster analysis was used to identify patterns of 
      premorbid functioning. Results indicated three patterns of premorbid functioning 
      in our CHR sample: stable-intermediate, stable-good, and deteriorating. The 
      deteriorating group had more severe disorganization, worse negative symptoms, and 
      poorer social functioning than the other groups. Participants who made the 
      conversion to psychosis had significantly poorer premorbid functioning during 
      adolescence compared to those who did not convert. These results suggest that 
      those at a clinical high risk for psychosis display similar patterns in premorbid 
      functioning as have been observed in those with a psychotic illness and that poor 
      premorbid functioning may be a predictor of psychosis.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Lyngberg, Kristina
AU  - Lyngberg K
AD  - Department of Neuroscience, Faculty of Science, University of Calgary, Calgary, 
      AB, Canada.
FAU - Buchy, Lisa
AU  - Buchy L
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, AB, Canada.
FAU - Liu, Lu
AU  - Liu L
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, AB, Canada.
FAU - Perkins, Diana
AU  - Perkins D
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, United 
      States.
FAU - Woods, Scott
AU  - Woods S
AD  - Department of Psychiatry, Yale University, New Haven, CT, United States.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, AB, Canada. Electronic address: jmadding@ucalgary.ca.
LA  - eng
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - U01MH066134/MH/NIMH NIH HHS/United States
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - U01MH066069/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - U01MH066160/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151114
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - *Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*diagnosis/*psychology
MH  - Severity of Illness Index
MH  - Social Adjustment
MH  - Young Adult
PMC - PMC5037436
MID - NIHMS740759
OTO - NOTNLM
OT  - Clinical high risk
OT  - Conversion
OT  - Premorbid functioning
OT  - Schizophrenia
OT  - Social functioning
OT  - Symptoms
EDAT- 2015/11/22 06:00
MHDA- 2016/09/27 06:00
PMCR- 2016/12/01
CRDT- 2015/11/22 06:00
PHST- 2015/08/14 00:00 [received]
PHST- 2015/11/02 00:00 [revised]
PHST- 2015/11/03 00:00 [accepted]
PHST- 2015/11/22 06:00 [entrez]
PHST- 2015/11/22 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - S0920-9964(15)30047-5 [pii]
AID - 10.1016/j.schres.2015.11.004 [doi]
PST - ppublish
SO  - Schizophr Res. 2015 Dec;169(1-3):209-213. doi: 10.1016/j.schres.2015.11.004. Epub 
      2015 Nov 14.