PMID- 26589514
OWN - NLM
STAT- MEDLINE
DCOM- 20161012
LR  - 20181113
IS  - 1432-1173 (Electronic)
IS  - 0017-8470 (Linking)
VI  - 67
IP  - 1
DP  - 2016 Jan
TI  - [Molecular diagnosis of melanocytic tumors].
PG  - 59-63
LID - 10.1007/s00105-015-3724-8 [doi]
AB  - Melanoma therapy has undergone a paradigm shift. Classic chemotherapies with poor 
      treatment responses have been replaced by modern immune checkpoint blockades and 
      targeted therapies with excellent responses. The latter require precise diagnosis 
      of mutations in the melanoma genome as molecular targets for the small molecules. 
      The diagnosis of melanomas has also been supplemented by molecular techniques. 
      Differential diagnosis of melanoma and melanoma simulators such as atypical Spitz 
      nevi can be supported by fluorescence in situ hybridization (FISH) and 
      comparative genomic hybridization (CGH). Here we review the indications and 
      methods for molecular diagnosis of melanocytic tumors.
FAU - Bauer, J
AU  - Bauer J
AD  - Universitats-Hautklinik, Liebermeisterstr. 25, 72076, Tubingen, Deutschland. 
      juergen.bauer@med.uni-tuebingen.de.
LA  - ger
PT  - Journal Article
PT  - Review
TT  - Molekulare Diagnostik bei melanozytaren Tumoren.
PL  - Germany
TA  - Hautarzt
JT  - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
JID - 0372755
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Evidence-Based Medicine
MH  - Genetic Predisposition to Disease/genetics
MH  - High-Throughput Nucleotide Sequencing/*methods
MH  - Humans
MH  - Melanoma/*diagnosis/*genetics
MH  - Molecular Diagnostic Techniques/*methods
MH  - Neoplasm Proteins/genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Skin Neoplasms/*diagnosis/*genetics
OTO - NOTNLM
OT  - Comparative genomic hybridization
OT  - DNA mutational analysis
OT  - Melanoma
OT  - Molecular targeted therapy
OT  - Spitz nevus
EDAT- 2015/11/22 06:00
MHDA- 2016/10/13 06:00
CRDT- 2015/11/22 06:00
PHST- 2015/11/22 06:00 [entrez]
PHST- 2015/11/22 06:00 [pubmed]
PHST- 2016/10/13 06:00 [medline]
AID - 10.1007/s00105-015-3724-8 [pii]
AID - 10.1007/s00105-015-3724-8 [doi]
PST - ppublish
SO  - Hautarzt. 2016 Jan;67(1):59-63. doi: 10.1007/s00105-015-3724-8.