PMID- 26589724
OWN - NLM
STAT- MEDLINE
DCOM- 20160601
LR  - 20211203
IS  - 1478-811X (Electronic)
IS  - 1478-811X (Linking)
VI  - 13
DP  - 2015 Nov 21
TI  - Vps34 and PLD1 take center stage in nutrient signaling: their dual roles in 
      regulating autophagy.
PG  - 44
LID - 10.1186/s12964-015-0122-x [doi]
LID - 44
AB  - Autophagy is a critical pathway leading to lysosomal degradation of cellular 
      components in response to changes in nutrient availability. Autophagy includes 
      the biogenesis of autophagosomes and their sequential maturation through fusion 
      with endo-lysosomes. The class III PI3 kinase Vps34 and its product 
      phosphatidylinositol-3-phosphate (PI(3)P) play a critical role in this process, 
      and enable the amino acid-mediated activation of mammalian target of rapamycin 
      (mTOR), a suppressor of autophagy. Recent studies have shown that phospholipase 
      PLD1, a downstream regulator of Vps34, is also closely involved in both mTOR 
      activation and autophagy. This mini review summarizes recent findings in the 
      regulation of Vps34 and PLD1 and highlights the role of these lipid-metabolizing 
      enzymes in both mTOR activation and autophagy.
FAU - Yoon, Mee-Sup
AU  - Yoon MS
AD  - Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 
      406-840, Korea. msyoon@gachon.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151121
PL  - England
TA  - Cell Commun Signal
JT  - Cell communication and signaling : CCS
JID - 101170464
RN  - 0 (Amino Acids)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.1.137 (Class III Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.1.4.4 (Phospholipase D)
RN  - EC 3.1.4.4 (phospholipase D1)
SB  - IM
MH  - Amino Acids/metabolism
MH  - Animals
MH  - *Autophagy
MH  - Class III Phosphatidylinositol 3-Kinases/*metabolism
MH  - Humans
MH  - Lipid Metabolism
MH  - Lysosomes/metabolism
MH  - Phospholipase D/*metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC4654845
EDAT- 2015/11/22 06:00
MHDA- 2016/06/02 06:00
PMCR- 2015/11/21
CRDT- 2015/11/22 06:00
PHST- 2015/09/19 00:00 [received]
PHST- 2015/11/18 00:00 [accepted]
PHST- 2015/11/22 06:00 [entrez]
PHST- 2015/11/22 06:00 [pubmed]
PHST- 2016/06/02 06:00 [medline]
PHST- 2015/11/21 00:00 [pmc-release]
AID - 10.1186/s12964-015-0122-x [pii]
AID - 122 [pii]
AID - 10.1186/s12964-015-0122-x [doi]
PST - epublish
SO  - Cell Commun Signal. 2015 Nov 21;13:44. doi: 10.1186/s12964-015-0122-x.