PMID- 26590234
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20161230
IS  - 1945-239X (Electronic)
IS  - 0021-9665 (Linking)
VI  - 54
IP  - 3
DP  - 2016 Mar
TI  - Application of Sigmoidal Transformation Functions in Optimization of Micellar 
      Liquid Chromatographic Separation of Six Quinolone Antibiotics.
PG  - 429-35
LID - 10.1093/chromsci/bmv164 [doi]
AB  - A chemometrics approach has been used to optimize the separation of six quinolone 
      compounds by micellar liquid chromatography (MLC). A Derringer's desirability 
      function, a multicriteria decision-making (MCDM) method, was tested for 
      evaluation of two different measures of chromatographic performance (resolution 
      and analysis time). The effect of three experimental parameters on a 
      chromatographic response function (CRF) expressed as a product of two sigmoidal 
      desirability functions was investigated. The sigmoidal functions were used to 
      transform the optimization criteria, resolution and analysis time into the 
      desirability values. The factors studied were the concentration of sodium dodecyl 
      sulfate, butanol content and pH of the mobile phase. The experiments were done 
      according to the face-centered cube central composite design, and the calculated 
      CRF values were fitted to a polynomial model to correlate the CRF values with the 
      variables and their interactions. The developed regression model showed good 
      descriptive and predictive ability (R(2) = 0.815, F = 6.919, SE = 0.038, 
      [Formula: see text]) and used, by a grid search algorithm, to optimize the 
      chromatographic conditions for the separation of the mixture. The efficiency of 
      prediction of polynomial model was confirmed by performing the experiment under 
      the optimal conditions.
CI  - (c) The Author 2015. Published by Oxford University Press. All rights reserved. For 
      Permissions, please email: journals.permissions@oup.com.
FAU - Hadjmohammadi, Mohammadreza
AU  - Hadjmohammadi M
AD  - Department of Analytical Chemistry, Faculty of Chemistry, University of 
      Mazandaran, Babolsar, Iran hadjmr@umz.ac.ir.
FAU - Salary, Mina
AU  - Salary M
AD  - Department of Analytical Chemistry, Faculty of Chemistry, University of 
      Mazandaran, Babolsar, Iran.
LA  - eng
PT  - Journal Article
DEP - 20151120
PL  - United States
TA  - J Chromatogr Sci
JT  - Journal of chromatographic science
JID - 0173225
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Ethylamines)
RN  - 0 (Micelles)
RN  - 0 (Phosphoric Acids)
RN  - 0 (Quinolones)
RN  - 0 (Solutions)
RN  - 0 (Solvents)
RN  - 368GB5141J (Sodium Dodecyl Sulfate)
RN  - 8PJ61P6TS3 (1-Butanol)
RN  - E4GA8884NN (phosphoric acid)
RN  - VOU728O6AY (triethylamine)
SB  - IM
MH  - 1-Butanol
MH  - Algorithms
MH  - Anti-Bacterial Agents/*isolation & purification
MH  - Chromatography, High Pressure Liquid/instrumentation/*methods
MH  - Ethylamines
MH  - Factor Analysis, Statistical
MH  - Hydrogen-Ion Concentration
MH  - Micelles
MH  - *Models, Statistical
MH  - Phosphoric Acids
MH  - Quinolones/*isolation & purification
MH  - Sodium Dodecyl Sulfate
MH  - Solutions
MH  - Solvents
EDAT- 2015/11/22 06:00
MHDA- 2016/11/01 06:00
CRDT- 2015/11/22 06:00
PHST- 2015/05/28 00:00 [received]
PHST- 2015/11/22 06:00 [entrez]
PHST- 2015/11/22 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
AID - bmv164 [pii]
AID - 10.1093/chromsci/bmv164 [doi]
PST - ppublish
SO  - J Chromatogr Sci. 2016 Mar;54(3):429-35. doi: 10.1093/chromsci/bmv164. Epub 2015 
      Nov 20.