PMID- 26590881
OWN - NLM
STAT- MEDLINE
DCOM- 20160624
LR  - 20151209
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1007
DP  - 2015 Dec 15
TI  - One-pot preparation of a novel monolith for high performance liquid 
      chromatography applications.
PG  - 100-9
LID - S1570-0232(15)30247-6 [pii]
LID - 10.1016/j.jchromb.2015.10.028 [doi]
AB  - Various novel porous organic-based monoliths with the mode of hydrophobicity were 
      synthesized by in situ free-radical crosslinking copolymerization and optimized 
      for the separations of small molecules and high-performance reversed-phase 
      chromatography (RP-chromatography). These monoliths contained co-polymers based 
      on glycidyl methacrylate (GMA)/ethylene glycol dimethacrylate (EDMA)/tripropylene 
      glycol diacrylate (TPGDA) or EDMA/TPGDA. A mixture of cetanol, methanol and poly 
      (ethylene glycol) (PEG) was used as the porogen, with the ratio of these solvents 
      being varied along with the polymerization temperature to generate a library of 
      monoliths. The conditions were optimized and the resulting poly 
      (GMA-co-TPGDA-co-EDMA) monolith was investigated by infrared spectrometer (IR), 
      field emission scanning electron microscope (FESEM), and mercury intrusion 
      porosimetry (MIP), respectively. The column performance was assessed by the 
      separation of a series of neutral solutes of benzene derivatives. The result 
      demonstrated that the prepared monolith exhibited an RP-chromatographic behavior 
      and relatively homogeneous structure, good permeability and separation 
      performance. Moreover, the relative standard deviations (RSDs) of the retention 
      factor values for benzene derivatives were less than 1.5% (n=7, 
      column-to-column). The approach used in this study was extended to the separation 
      of anilines.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Jiao, Xiaoyan
AU  - Jiao X
AD  - Key Laboratory of Analytical Science and Technology of Hebei Province, College of 
      Chemistry and Environmental Science, Hebei University, Baoding 071002, China; 
      College of Science, Hebei North University, Zhangjiakou, 075000, China.
FAU - Shen, Shigang
AU  - Shen S
AD  - Key Laboratory of Analytical Science and Technology of Hebei Province, College of 
      Chemistry and Environmental Science, Hebei University, Baoding 071002, China. 
      Electronic address: shensg@hbu.cn.
FAU - Shi, Tiesheng
AU  - Shi T
AD  - Key Laboratory of Analytical Science and Technology of Hebei Province, College of 
      Chemistry and Environmental Science, Hebei University, Baoding 071002, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151111
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Benzene Derivatives)
SB  - IM
MH  - Benzene Derivatives/isolation & purification
MH  - Chromatography, High Pressure Liquid/*instrumentation
MH  - Chromatography, Reverse-Phase/*instrumentation
MH  - Microscopy, Electron, Scanning
MH  - Reproducibility of Results
MH  - Spectrophotometry, Infrared
OTO - NOTNLM
OT  - High performance liquid chromatography (HPLC)
OT  - Mixed-mode polymer monolith
OT  - Organic polymeric monolith
OT  - Small molecules
OT  - Tripropylene glycol diacrylate
EDAT- 2015/11/23 06:00
MHDA- 2016/06/25 06:00
CRDT- 2015/11/23 06:00
PHST- 2015/07/08 00:00 [received]
PHST- 2015/10/18 00:00 [revised]
PHST- 2015/10/20 00:00 [accepted]
PHST- 2015/11/23 06:00 [entrez]
PHST- 2015/11/23 06:00 [pubmed]
PHST- 2016/06/25 06:00 [medline]
AID - S1570-0232(15)30247-6 [pii]
AID - 10.1016/j.jchromb.2015.10.028 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 15;1007:100-9. doi: 
      10.1016/j.jchromb.2015.10.028. Epub 2015 Nov 11.