PMID- 26592835
OWN - NLM
STAT- MEDLINE
DCOM- 20160701
LR  - 20181202
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 19
IP  - 21
DP  - 2015 Nov
TI  - Use of proton pump inhibitors in hematopoietic stem cell transplantation does not 
      increase the frequency of febrile neutropenia.
PG  - 4105-10
LID - 9767 [pii]
AB  - OBJECTIVE: Despite the fact that proton pump inhibitor (PPI) use is a risk factor 
      for infections in heterogeneous groups of patients, there are only a limited data 
      related to PPI use and febrile neutropenic episodes (FNEs) in hematopoietic stem 
      cell transplantation (HSCT) patients. PATIENTS AND METHODS: In a 7-year period, 
      we retrospectively reviewed 145 HSCT data to identify a risk factor for PPI use 
      for febrile neutropenia. The follow-up process of 125 (86.2%) of the HSCTs was 
      complicated with FNEs. RESULTS: A multivariate analysis indicated that PPI use 
      was not significantly associated with FNEs (Odds ratio [OR]: 0.46; 95% Confidence 
      Interval [CI] 0.12-2.16; p = 0.24) or bacterial culture positivity (OR: 1.37; 95% 
      CI 0.45-4.18; p = 0.58). CONCLUSIONS: Our study revealed that PPI use does not 
      appear to be a risk factor for FNE or bacterial culture positivity for HSCT 
      patients but further studies are needed.
FAU - Ozkan, M C
AU  - Ozkan MC
AD  - Department of Hematology, Internal Medicine, and Microbiology; Ege University 
      Medical School, Izmir, Turkey. zjdocchina@163.com.
FAU - Donmez, A
AU  - Donmez A
FAU - Arslan, A
AU  - Arslan A
FAU - Aydemir, S
AU  - Aydemir S
FAU - Tombuloglu, M
AU  - Tombuloglu M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Febrile Neutropenia/chemically induced/*diagnosis/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Hematopoietic Stem Cell Transplantation/adverse effects/*trends
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/adverse effects/*therapeutic use
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
EDAT- 2015/11/26 06:00
MHDA- 2016/07/02 06:00
CRDT- 2015/11/24 06:00
PHST- 2015/11/24 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/07/02 06:00 [medline]
AID - 9767 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2015 Nov;19(21):4105-10.