PMID- 26593773
OWN - NLM
STAT- MEDLINE
DCOM- 20160824
LR  - 20221115
IS  - 1528-8951 (Electronic)
IS  - 0148-0731 (Print)
IS  - 0148-0731 (Linking)
VI  - 138
IP  - 1
DP  - 2016 Jan
TI  - Computationally Optimizing the Compliance of a Biopolymer Based Tissue Engineered 
      Vascular Graft.
PG  - 0145051-5
LID - 10.1115/1.4032060 [doi]
AB  - Coronary heart disease is a leading cause of death among Americans for which 
      coronary artery bypass graft (CABG) surgery is a standard surgical treatment. The 
      success of CABG surgery is impaired by a compliance mismatch between vascular 
      grafts and native vessels. Tissue engineered vascular grafts (TEVGs) have the 
      potential to be compliance matched and thereby reduce the risk of graft failure. 
      Glutaraldehyde (GLUT) vapor-crosslinked gelatin/fibrinogen constructs were 
      fabricated and mechanically tested in a previous study by our research group at 
      2, 8, and 24 hrs of GLUT vapor exposure. The current study details a 
      computational method that was developed to predict the material properties of our 
      constructs for crosslinking times between 2 and 24 hrs by interpolating the 2, 8, 
      and 24 hrs crosslinking time data. matlab and abaqus were used to determine the 
      optimal combination of fabrication parameters to produce a compliance matched 
      construct. The validity of the method was tested by creating a 16-hr crosslinked 
      construct of 130 mum thickness and comparing its compliance to that predicted by 
      the optimization algorithm. The predicted compliance of the 16-hr construct was 
      0.00059 mm Hg-1 while the experimentally determined compliance was 0.00065 mm 
      Hg-1, a relative difference of 9.2%. Prior data in our laboratory has shown the 
      compliance of the left anterior descending porcine coronary (LADC) artery to be 
      0.00071 +/- 0.0003 mm Hg-1. Our optimization algorithm predicts that a 258-mum-thick 
      construct that is GLUT vapor crosslinked for 8.1 hrs would match LADC compliance. 
      This result is consistent with our previous work demonstrating that an 8-hr GLUT 
      vapor crosslinked construct produces a compliance that is not significantly 
      different from a porcine coronary LADC.
FAU - Harrison, Scott
AU  - Harrison S
FAU - Tamimi, Ehab
AU  - Tamimi E
FAU - Uhlorn, Josh
AU  - Uhlorn J
FAU - Leach, Tim
AU  - Leach T
FAU - Vande Geest, Jonathan P
AU  - Vande Geest JP
LA  - eng
GR  - R21 HL111990/HL/NHLBI NIH HHS/United States
GR  - 1R21HL111990/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Biomech Eng
JT  - Journal of biomechanical engineering
JID - 7909584
RN  - 9000-70-8 (Gelatin)
RN  - 9001-32-5 (Fibrinogen)
RN  - T3C89M417N (Glutaral)
SB  - IM
MH  - Animals
MH  - *Blood Vessel Prosthesis
MH  - Cattle
MH  - Computer Simulation
MH  - Coronary Vessels
MH  - Electricity
MH  - Fibrinogen/*chemistry
MH  - Gelatin/*chemistry
MH  - Glutaral/chemistry
MH  - Materials Testing
MH  - *Mechanical Phenomena
MH  - Prosthesis Design/instrumentation/*methods
MH  - Swine
MH  - Time Factors
PMC - PMC4845160
EDAT- 2015/11/26 06:00
MHDA- 2016/08/25 06:00
PMCR- 2017/01/01
CRDT- 2015/11/24 06:00
PHST- 2015/09/11 00:00 [received]
PHST- 2015/11/24 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/08/25 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 2473573 [pii]
AID - BIO-15-1447 [pii]
AID - 10.1115/1.4032060 [doi]
PST - ppublish
SO  - J Biomech Eng. 2016 Jan;138(1):0145051-5. doi: 10.1115/1.4032060.