PMID- 26594139
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151123
LR  - 20220321
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 9
DP  - 2015
TI  - Glutamatergic transmission in drug reward: implications for drug addiction.
PG  - 404
LID - 10.3389/fnins.2015.00404 [doi]
LID - 404
AB  - Individuals addicted to drugs of abuse such as alcohol, nicotine, cocaine, and 
      heroin are a significant burden on healthcare systems all over the world. The 
      positive reinforcing (rewarding) effects of the above mentioned drugs play a 
      major role in the initiation and maintenance of the drug-taking habit. Thus, 
      understanding the neurochemical mechanisms underlying the reinforcing effects of 
      drugs of abuse is critical to reducing the burden of drug addiction in society. 
      Over the last two decades, there has been an increasing focus on the role of the 
      excitatory neurotransmitter glutamate in drug addiction. In this review, 
      pharmacological and genetic evidence supporting the role of glutamate in 
      mediating the rewarding effects of the above described drugs of abuse will be 
      discussed. Further, the review will discuss the role of glutamate transmission in 
      two complex heterogeneous brain regions, namely the nucleus accumbens (NAcc) and 
      the ventral tegmental area (VTA), which mediate the rewarding effects of drugs of 
      abuse. In addition, several medications approved by the Food and Drug 
      Administration that act by blocking glutamate transmission will be discussed in 
      the context of drug reward. Finally, this review will discuss future studies 
      needed to address currently unanswered gaps in knowledge, which will further 
      elucidate the role of glutamate in the rewarding effects of drugs of abuse.
FAU - D'Souza, Manoranjan S
AU  - D'Souza MS
AD  - Pharmaceutical and Biomedical Sciences, Raabe College of Pharmacy, Ohio Northern 
      University Ada, OH, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151105
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC4633516
OTO - NOTNLM
OT  - alcohol
OT  - cocaine
OT  - heroin
OT  - microdialysis
OT  - nicotine
OT  - nucleus accumbens
OT  - prefrontal cortex
OT  - reward
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/01/01
CRDT- 2015/11/24 06:00
PHST- 2015/07/31 00:00 [received]
PHST- 2015/10/12 00:00 [accepted]
PHST- 2015/11/24 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2015.00404 [doi]
PST - epublish
SO  - Front Neurosci. 2015 Nov 5;9:404. doi: 10.3389/fnins.2015.00404. eCollection 
      2015.