PMID- 26596505
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20171116
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 153
DP  - 2015 Dec
TI  - Chiral manganese (IV) complexes derived from Schiff base ligands: Synthesis, 
      characterization, in vitro cytotoxicity and DNA/BSA interaction.
PG  - 473-82
LID - S1011-1344(15)00370-X [pii]
LID - 10.1016/j.jphotobiol.2015.11.005 [doi]
AB  - Two new couples of chiral manganese (IV) complexes with Schiff-base ligands, 
      Lambda-[Mn(R-L(1))2].2(CH3OH) (Lambda-1) and Delta-[Mn(S-L(1))2].2(CH3OH) (Delta-1), 
      Lambda-[Mn(R-L(2))2].(H2O)2 (Lambda-2) and Delta-[Mn(S-L(2))2].(H2O)2 (Delta-2), 
      H2L(1)=(R/S)-(+/-)-1-[(1-hydroxymethyl-propylimino)-methyl]-naphthalen-2-ol, 
      H2L(2)=(R/S)-(+/-)-1-[(1-Hydroxymethyl-2-phenyl-ethylimino)-methyl]-naphthalen-2-ol 
      have been synthesized, and fully characterized by elemental analyses, UV-Vis 
      spectrum, circular dichroism spectrum, FT-IR spectrum, mass spectrum, and single 
      crystal X-ray diffraction (SXRD). The interaction of the four chiral Mn (IV) 
      complexes with CT-DNA and BSA were also investigated by various spectroscopic 
      techniques (UV-visible, fluorescence spectroscopic). The results show that the 
      Delta-complexes exhibit more efficient CT-DNA interaction with respect to the 
      Lambda-complexes. All the complexes could quench the intrinsic fluorescence of BSA by 
      a static quenching process. In addition, the vitro cytotoxicity of these 
      complexes toward four kinds of cancerous cell lines (A549, HeLa, HL-60, and 
      Caco-2) was assayed by the MTT method, which exhibited to be selectively active 
      against certain cell lines.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Li, Zhen
AU  - Li Z
AD  - Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell 
      Technology, College of Chemistry and Chemical Engineering, Liaocheng University, 
      Liaocheng, Shandong 252059, China.
FAU - Niu, Meiju
AU  - Niu M
AD  - Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell 
      Technology, College of Chemistry and Chemical Engineering, Liaocheng University, 
      Liaocheng, Shandong 252059, China. Electronic address: niumeiju@163.com.
FAU - Chang, Guoliang
AU  - Chang G
AD  - Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell 
      Technology, College of Chemistry and Chemical Engineering, Liaocheng University, 
      Liaocheng, Shandong 252059, China.
FAU - Zhao, Changqiu
AU  - Zhao C
AD  - Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell 
      Technology, College of Chemistry and Chemical Engineering, Liaocheng University, 
      Liaocheng, Shandong 252059, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151107
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Coordination Complexes)
RN  - 0 (Ligands)
RN  - 0 (Schiff Bases)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 42Z2K6ZL8P (Manganese)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Caco-2 Cells
MH  - Cell Survival/drug effects
MH  - Circular Dichroism
MH  - Coordination Complexes/*chemical synthesis/metabolism/toxicity
MH  - Crystallography, X-Ray
MH  - DNA/chemistry/*metabolism
MH  - HL-60 Cells
MH  - HeLa Cells
MH  - Humans
MH  - Ligands
MH  - Manganese/*chemistry
MH  - Mass Spectrometry
MH  - Molecular Conformation
MH  - Protein Binding
MH  - Schiff Bases/*chemistry
MH  - Serum Albumin, Bovine/chemistry/*metabolism
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Stereoisomerism
OTO - NOTNLM
OT  - BSA interaction
OT  - Chiral Schiff-base
OT  - Cytotoxicity
OT  - DNA binding
OT  - Manganese complexes
EDAT- 2015/11/26 06:00
MHDA- 2016/10/07 06:00
CRDT- 2015/11/25 06:00
PHST- 2015/08/03 00:00 [received]
PHST- 2015/11/05 00:00 [revised]
PHST- 2015/11/06 00:00 [accepted]
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - S1011-1344(15)00370-X [pii]
AID - 10.1016/j.jphotobiol.2015.11.005 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2015 Dec;153:473-82. doi: 
      10.1016/j.jphotobiol.2015.11.005. Epub 2015 Nov 7.