PMID- 26596791
OWN - NLM
STAT- MEDLINE
DCOM- 20160506
LR  - 20201218
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 102
IP  - 2
DP  - 2016 Jan
TI  - Aortic valve prosthesis-patient mismatch and exercise capacity in adult patients 
      with congenital heart disease.
PG  - 107-13
LID - 10.1136/heartjnl-2015-308013 [doi]
AB  - OBJECTIVES: To report the prevalence of aortic valve prosthesis-patient mismatch 
      (PPM) in an adult population with congenital heart disease (CHD) and its impact 
      on exercise capacity. Adults with congenital heart disease (ACHD) with a history 
      of aortic valve replacement may outgrow their prosthesis later in life. However, 
      the prevalence and clinical consequences of aortic PPM in ACHD are presently 
      unknown. METHODS: From the national Dutch Congenital Corvitia (CONCOR) registry, 
      we identified 207 ACHD with an aortic valve prosthesis for this cross-sectional 
      cohort study. Severe PPM was defined as an indexed effective orifice area 
      </=0.65 cm2/m2 and moderate PPM as an indexed orifice area </=0.85 cm2/m2 measured 
      using echocardiography. Exercise capacity was reported as percentage of predicted 
      exercise capacity (PPEC). RESULTS: Of the 207 patients, 68% was male, 71% had a 
      mechanical prosthesis and mean age at inclusion was 43.9 years +/-11.4. The 
      prevalence of PPM was 42%, comprising 23% severe PPM and 19% moderate PPM. 
      Prevalence of PPM was higher in patients with mechanical prostheses (p<0.001). 
      PPM was associated with poorer exercise capacity (mean PPEC 84% vs. 92%; p=0.048, 
      mean difference =-8.3%, p=0.047). Mean follow-up was 2.6+/-1.1 years during which 
      New York Heart Association (NYHA) class remained stable in most patients. PPM 
      showed no significant effect on death or hospitalisation during follow-up 
      (p=0.218). CONCLUSIONS: In this study we report a high prevalence (42%) of PPM in 
      ACHD with an aortic valve prosthesis and an independent association of PPM with 
      diminished exercise capacity.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/
FAU - van Slooten, Ymkje J
AU  - van Slooten YJ
AD  - Department of Cardiology, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands Department of Thoracic Surgery, University 
      Medical Center Groningen, University of Groningen, Groningen, The Netherlands 
      Interuniversity Cardiology Institute of the Netherlands, Utrecht, The 
      Netherlands.
FAU - van Melle, Joost P
AU  - van Melle JP
AD  - Department of Cardiology, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands.
FAU - Freling, Hendrik G
AU  - Freling HG
AD  - Department of Cardiology, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands Interuniversity Cardiology Institute of the 
      Netherlands, Utrecht, The Netherlands Department of Radiology, University Medical 
      Center Groningen, University of Groningen, Groningen, The Netherlands.
FAU - Bouma, Berto J
AU  - Bouma BJ
AD  - Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
FAU - van Dijk, Arie Pj
AU  - van Dijk AP
AD  - Department of Cardiology, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
FAU - Jongbloed, Monique Rm
AU  - Jongbloed MR
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Post, Martijn C
AU  - Post MC
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Sieswerda, Gertjan T
AU  - Sieswerda GT
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Huis In 't Veld, Anna
AU  - Huis In 't Veld A
AD  - Department of Cardiology, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands.
FAU - Ebels, Tjark
AU  - Ebels T
AD  - Department of Thoracic Surgery, University Medical Center Groningen, University 
      of Groningen, Groningen, The Netherlands.
FAU - Voors, Adriaan A
AU  - Voors AA
AD  - Department of Cardiology, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands.
FAU - Pieper, Petronella G
AU  - Pieper PG
AD  - Department of Cardiology, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151123
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
CIN - Heart. 2016 Jan;102(2):89-90. PMID: 26608652
MH  - Adult
MH  - Aortic Valve/physiopathology/surgery
MH  - Bicuspid Aortic Valve Disease
MH  - Exercise Test/methods
MH  - *Exercise Tolerance
MH  - Female
MH  - *Heart Defects, Congenital/diagnosis/etiology/physiopathology/surgery
MH  - *Heart Valve Diseases/diagnosis/etiology/physiopathology/surgery
MH  - *Heart Valve Prosthesis/adverse effects/standards
MH  - Heart Valve Prosthesis Implantation/*adverse effects/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Postoperative Complications/diagnosis/epidemiology/physiopathology
MH  - Prevalence
MH  - Prosthesis Failure/*etiology
MH  - *Registries
MH  - Treatment Outcome
EDAT- 2015/11/26 06:00
MHDA- 2016/05/07 06:00
CRDT- 2015/11/25 06:00
PHST- 2015/06/17 00:00 [received]
PHST- 2015/10/19 00:00 [accepted]
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/05/07 06:00 [medline]
AID - heartjnl-2015-308013 [pii]
AID - 10.1136/heartjnl-2015-308013 [doi]
PST - ppublish
SO  - Heart. 2016 Jan;102(2):107-13. doi: 10.1136/heartjnl-2015-308013. Epub 2015 Nov 
      23.