PMID- 26597605
OWN - NLM
STAT- MEDLINE
DCOM- 20160929
LR  - 20151218
IS  - 1773-0619 (Electronic)
IS  - 0028-3770 (Linking)
VI  - 61
IP  - 6
DP  - 2015 Dec
TI  - Adult recurrent pilocytic astrocytoma: Clinical, histopathological and molecular 
      study.
PG  - 392-7
LID - S0028-3770(15)00246-5 [pii]
LID - 10.1016/j.neuchi.2015.07.002 [doi]
AB  - BACKGROUND: PA is a grade I glial tumor that mostly occurs in children. However, 
      although apparently similar to paediatric PA, adult PA presents a different 
      clinical follow-up that could arise from specific molecular alterations. A 
      variety of genetic alterations have been identified as diagnostic or prognostic 
      glioma molecular markers. MATERIAL AND METHODS: We describe a right 
      infratentorial tumor that occurred in a 58-year-old man. Neuroimaging and 
      neuropathological examination suggested PA as an initial diagnosis. The tumor was 
      completely resected. Unexpectedly, two years later, a rapidly growing tumor on 
      the operative site was observed with a second location in the pineal region. 
      Immunohistochemical reactions (IHC), Multiplex ligation probe amplification 
      (MLPA) and fluorescence in situ hybridization (FISH) was performed in both 
      primary and relapse tumor. RESULTS: Neuroimaging and neuropathological 
      examinations suggested an unusual diagnosis for adult patients: a recurrent PA. 
      Both MLPA and FISH analysis contribute to diagnostic confirmation by KIAA1549: 
      BRAF fusion detection. Additional genetic results revealed interesting findings 
      that justified the tumor aggressivity. CONCLUSION: Molecular analysis of adult PA 
      cases should be routinely combined with histopathological and neuroimaging 
      examination to further refine prognostic diagnoses.
CI  - Copyright (c) 2015 Elsevier Masson SAS. All rights reserved.
FAU - Trabelsi, S
AU  - Trabelsi S
AD  - Department of Cytogenetics, Molecular genetics and Reproductive Biology, Farhat 
      Hached University Hospital, Street Ibn Eljazzar, 4000 Sousse, Tunisia. Electronic 
      address: tsaoussen@yahoo.fr.
FAU - Mama, N
AU  - Mama N
AD  - Department of Imagery, Sahloul University Hospital, Sousse, Tunisia.
FAU - Ladib, M
AU  - Ladib M
AD  - Department of Neurosurgery, Sahloul University Hospital, Sousse, Tunisia.
FAU - Popov, S
AU  - Popov S
AD  - Divisions of Molecular Pathology and Cancer Therapeutics, the Institute of Cancer 
      Research, Sutton, United Kingdom.
FAU - Burford, A
AU  - Burford A
AD  - Divisions of Molecular Pathology and Cancer Therapeutics, the Institute of Cancer 
      Research, Sutton, United Kingdom.
FAU - Mokni, M
AU  - Mokni M
AD  - Department of Cytopathology, Farhat Hached University Hospital, Sousse, Tunisia.
FAU - Tlili, K
AU  - Tlili K
AD  - Department of Imagery, Sahloul University Hospital, Sousse, Tunisia.
FAU - Krifa, H
AU  - Krifa H
AD  - Department of Neurosurgery, Sahloul University Hospital, Sousse, Tunisia.
FAU - Varella-Garcia, M
AU  - Varella-Garcia M
AD  - University of Colorado Denver School of Medicine, Division of Medical Oncology, 
      Colorado, USA.
FAU - Jones, C
AU  - Jones C
AD  - Divisions of Molecular Pathology and Cancer Therapeutics, the Institute of Cancer 
      Research, Sutton, United Kingdom.
FAU - Tahar Yacoubi, M
AU  - Tahar Yacoubi M
AD  - Department of Cytopathology, Farhat Hached University Hospital, Sousse, Tunisia.
FAU - Saad, A
AU  - Saad A
AD  - Department of Cytogenetics, Molecular genetics and Reproductive Biology, Farhat 
      Hached University Hospital, Street Ibn Eljazzar, 4000 Sousse, Tunisia.
FAU - H'mida Ben Brahim, D
AU  - H'mida Ben Brahim D
AD  - Department of Cytogenetics, Molecular genetics and Reproductive Biology, Farhat 
      Hached University Hospital, Street Ibn Eljazzar, 4000 Sousse, Tunisia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20151117
PL  - France
TA  - Neurochirurgie
JT  - Neuro-Chirurgie
JID - 0401057
SB  - IM
MH  - Astrocytoma/*diagnosis
MH  - Humans
MH  - Infratentorial Neoplasms/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Molecular Diagnostic Techniques
MH  - Neoplasm Recurrence, Local/*diagnosis
OTO - NOTNLM
OT  - Adult
OT  - Adulte
OT  - Astrocytome pilocytique
OT  - Gene de fusion KIAA1549:BRAF
OT  - KIAA1549:BRAF fusion
OT  - Pilocytic astrocytoma
OT  - Recurrence
OT  - Recidive
EDAT- 2015/11/26 06:00
MHDA- 2016/09/30 06:00
CRDT- 2015/11/25 06:00
PHST- 2015/03/14 00:00 [received]
PHST- 2015/06/09 00:00 [revised]
PHST- 2015/07/29 00:00 [accepted]
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/09/30 06:00 [medline]
AID - S0028-3770(15)00246-5 [pii]
AID - 10.1016/j.neuchi.2015.07.002 [doi]
PST - ppublish
SO  - Neurochirurgie. 2015 Dec;61(6):392-7. doi: 10.1016/j.neuchi.2015.07.002. Epub 
      2015 Nov 17.