PMID- 26598138
OWN - NLM
STAT- MEDLINE
DCOM- 20160429
LR  - 20151231
IS  - 1873-6971 (Electronic)
IS  - 0367-326X (Linking)
VI  - 108
DP  - 2016 Jan
TI  - Monoterpene derivatives with anti-allergic activity from red peony root, the root 
      of Paeonia lactiflora.
PG  - 55-61
LID - S0367-326X(15)30120-9 [pii]
LID - 10.1016/j.fitote.2015.11.011 [doi]
AB  - The methanolic extract and its subfractions from red peony root, the dried roots 
      of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of 
      immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 
      cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene 
      derivatives, including 3 new compounds, paeoniflorol (1), 
      4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known 
      ones (4-16). The chemical structures of the new compounds were elucidated on the 
      basis of spectroscopic and chemical evidences. Among the isolated monoterpene 
      derivatives, nine compounds showed potent anti-allergic effects and compound 1 
      was the most effective. A primary structure-activity relationship of monoterpene 
      derivatives was discussed.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Shi, Yan-Hong
AU  - Shi YH
AD  - Division of Pharmacognosy, Department of Medicinal Resources, Institute of 
      Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
FAU - Zhu, Shu
AU  - Zhu S
AD  - Division of Pharmacognosy, Department of Medicinal Resources, Institute of 
      Natural Medicine, University of Toyama, Toyama 930-0194, Japan. Electronic 
      address: szhu@inm.u-toyama.ac.jp.
FAU - Ge, Yue-Wei
AU  - Ge YW
AD  - Division of Pharmacognosy, Department of Medicinal Resources, Institute of 
      Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
FAU - He, Yu-Min
AU  - He YM
AD  - Division of Pharmacognosy, Department of Medicinal Resources, Institute of 
      Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
FAU - Kazuma, Kohei
AU  - Kazuma K
AD  - Division of Kampo-Pharmaceutics, Department of Medicinal Resources, Institute of 
      Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
FAU - Wang, Zhengtao
AU  - Wang Z
AD  - The MOE Key laboratory of Standardization of Chinese Medicines, Institute of 
      Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 
      Shanghai 201-203, China.
FAU - Yoshimatsu, Kayo
AU  - Yoshimatsu K
AD  - Research Center for Medicinal Plant Resources, National Institute of Biomedical 
      Innovation, Health and Nutrition, Ibaraki 305-0843, Japan.
FAU - Komatsu, Katsuko
AU  - Komatsu K
AD  - Division of Pharmacognosy, Department of Medicinal Resources, Institute of 
      Natural Medicine, University of Toyama, Toyama 930-0194, Japan. Electronic 
      address: katsukok@inm.u-toyama.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151118
PL  - Netherlands
TA  - Fitoterapia
JT  - Fitoterapia
JID - 16930290R
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Monoterpenes)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/isolation & purification/*pharmacology
MH  - Cell Line, Tumor
MH  - Molecular Structure
MH  - Monoterpenes/isolation & purification/*pharmacology
MH  - Paeonia/*chemistry
MH  - Plant Extracts/chemistry
MH  - Plant Roots/*chemistry
MH  - Rats
OTO - NOTNLM
OT  - Anti-allergic activity
OT  - Monoterpene derivatives
OT  - Paeonia lactiflora
OT  - Red peony root
EDAT- 2015/11/26 06:00
MHDA- 2016/04/30 06:00
CRDT- 2015/11/25 06:00
PHST- 2015/09/09 00:00 [received]
PHST- 2015/11/13 00:00 [revised]
PHST- 2015/11/14 00:00 [accepted]
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/04/30 06:00 [medline]
AID - S0367-326X(15)30120-9 [pii]
AID - 10.1016/j.fitote.2015.11.011 [doi]
PST - ppublish
SO  - Fitoterapia. 2016 Jan;108:55-61. doi: 10.1016/j.fitote.2015.11.011. Epub 2015 Nov 
      18.