PMID- 26598194
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20181202
IS  - 1006-7248 (Print)
IS  - 1006-7248 (Linking)
VI  - 24
IP  - 5
DP  - 2015 Oct
TI  - [The relationship between chronic periodontitis and the instability of carotid 
      atherosclerotic plaque by serum level of MMP-9, MCP-1 and MMP-7].
PG  - 589-93
AB  - PURPOSE: To study the serum level of matrix metalloproteinase-9 (MMP-9), matrix 
      metalloproteinase-7(MMP-7) and monocyte chemo attractant protein-1(MCP-1) in 
      patients with chronic periodontitis in whom the stability of carotid 
      atherosclerotic plaque is affected. METHODS: One hundred and twenty-nine patients 
      were collected from People's Hospital of Liaoning Province, and divided into 3 
      groups. Group A (healthy group): 32 cases; Group B (periodontitis group): 31 
      cases; Group C (periodontitis with carotid atherosclerosis plaque group): 66 
      cases. According to carotid atherosclerotic plaque stability, Group C was further 
      divided into carotid atherosclerotic plaque stable subgroup (C1, 30 cases) and 
      unstable subgroup (C2, 36 cases). Each patient received periodontal examination, 
      and serum levels of MMP-9, MMP-7, MCP-1 were assayed by ELISA. The data was 
      statistically analyzed with SPSS19.0 software package. RESULTS: The age, gender, 
      drinking and smoking history in each group had no significant difference 
      (P>0.05). The periodontal baseline status in group B was worse than group A, in 
      group C was worse than group B and in group C2 was worse than group C1, and the 
      differences were significant (P<0.05). Serum level of MMP-9, MCP-1 and MMP-7 in 
      group C was significantly higher than in group B and group A (P<0.05), and in 
      group B were significantly higher than group A (P<0.05), in group C2 was 
      significantly higher than in group C1 (P<0.05). Serum level of MMP-9, MCP-1 and 
      MMP-7 were correlated with carotid atherosclerotic plaque stability (r=0.989, 
      P<0.05; r=0.605, P<0.05; r=0.389, P<0.05, respectively). CONCLUSIONS: Serum 
      inflammatory cytokines MMP-9, MMP-7 and MCP-1 are associated with the development 
      of periodontitis. The serum inflammatory cytokines MMP-9, MCP-1, MMP-7 as 
      mediating factors may indicate the severity of periodontal disease and affect the 
      stability of carotid atherosclerotic plaques.
FAU - Li, Feng
AU  - Li F
AD  - Department of Stomatology, People's Hospital of Liaoning Province. Shenyang 
      110016, Liaoning Province, China. E-mail: lnslifeng@163.com.
FAU - Sun, Xiao-ju
AU  - Sun XJ
FAU - Xie, Hong
AU  - Xie H
FAU - Wang, Yun
AU  - Wang Y
FAU - Zhang, Ying-kun
AU  - Zhang YK
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Shanghai Kou Qiang Yi Xue
JT  - Shanghai kou qiang yi xue = Shanghai journal of stomatology
JID - 101090220
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - EC 3.4.24.23 (Matrix Metalloproteinase 7)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Carotid Artery Diseases/*blood/epidemiology
MH  - Chemokine CCL2/*blood
MH  - China/epidemiology
MH  - Chronic Periodontitis/*blood/epidemiology
MH  - Humans
MH  - Matrix Metalloproteinase 7/*blood
MH  - Matrix Metalloproteinase 9/*blood
MH  - *Plaque, Atherosclerotic
EDAT- 2015/11/26 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/11/25 06:00
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
PST - ppublish
SO  - Shanghai Kou Qiang Yi Xue. 2015 Oct;24(5):589-93.