PMID- 26598587
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151124
LR  - 20200930
IS  - 1738-1088 (Print)
IS  - 2093-4327 (Electronic)
IS  - 1738-1088 (Linking)
VI  - 13
IP  - 3
DP  - 2015 Dec 31
TI  - Brain-derived Neurotrophic Factor Is Associated with Cognitive Impairment in 
      Elderly Korean Individuals.
PG  - 283-7
LID - 10.9758/cpn.2015.13.3.283 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is 
      widely expressed in the mammalian brain and acts to regulate neuronal survival 
      and influence cognitive processes. The present study measured serum BDNF levels 
      to investigate the associations of the BDNF Val66Met and 5-hydroxytryptamine 
      transporter linked promoter region (5-HTTLPR) polymorphisms with cognitive 
      function in elderly Korean individuals. METHODS: Over 60 years, a total of 834 
      subjects were recruited for the present study. The subjects were classified into 
      groups based on the degree of cognitive impairment (age-associated cognitive 
      decline, mild cognitive impairment, and Alzheimer's disease) and compared with 
      normal controls in terms of a neuropsychological assessment and a clinical 
      evaluation. RESULTS: Of the initial 834 study participants, 165 (59 controls and 
      106 subjects with cognitive impairments) completed the study. There was a 
      significant increase in serum BDNF levels in subjects with cognitive impairments 
      relative to the control group and the BDNF Val66Met polymorphism was 
      significantly associated with cognitive function but not serum BDNF levels. The 
      5-HTTLPR polymorphism did not have any associations with cognitive impairment or 
      serum BDNF levels. CONCLUSION: The present findings suggest that BDNF may play a 
      role in the pathophysiology of cognitive impairment and the BDNF Val66Met 
      polymorphism may be an important factor in the susceptibility to these 
      age-related deficits.
FAU - Lee, Sang Jun
AU  - Lee SJ
AD  - Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, Korea.
FAU - Baek, Jun-Hyung
AU  - Baek JH
AD  - Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, Korea.
FAU - Kim, Young-Hoon
AU  - Kim YH
AD  - Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, Korea.
AD  - Paik Institute for Clinical Research, Inje University College of Medicine, Busan, 
      Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Clin Psychopharmacol Neurosci
JT  - Clinical psychopharmacology and neuroscience : the official scientific journal of 
      the Korean College of Neuropsychopharmacology
JID - 101207332
PMC - PMC4662173
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Cognition
OT  - Dementia
OT  - Genetic polymorphism
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/12/01
CRDT- 2015/11/25 06:00
PHST- 2014/11/12 00:00 [received]
PHST- 2015/03/03 00:00 [revised]
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - cpn.2015.13.3.283 [pii]
AID - cpn-13-283 [pii]
AID - 10.9758/cpn.2015.13.3.283 [doi]
PST - ppublish
SO  - Clin Psychopharmacol Neurosci. 2015 Dec 31;13(3):283-7. doi: 
      10.9758/cpn.2015.13.3.283.