PMID- 26598917
OWN - NLM
STAT- MEDLINE
DCOM- 20160111
LR  - 20220330
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 22
IP  - 13
DP  - 2015 Dec 1
TI  - Antidepressant-like effect of the water extract of the fixed combination of 
      Gardenia jasminoides, Citrus aurantium and Magnolia officinalis in a rat model of 
      chronic unpredictable mild stress.
PG  - 1178-85
LID - S0944-7113(15)00280-9 [pii]
LID - 10.1016/j.phymed.2015.09.004 [doi]
AB  - BACKGROUND: Water extract of the fixed combination of Gardenia jasminoides Ellis 
      fruit, Citrus aurantium L. fruit and Magnolia officinalis Rehd. et Wils. bark, 
      traditional name - Zhi-Zi-Hou-Po (ZZHPD) is used for treatment of depressive-like 
      symptoms in traditional Chinese medicine for centuries. HYPOTHESIS/PURPOSE: The 
      present study aimed to explore antidepressant-like effects and potential 
      mechanisms of ZZHPD in a rat model of chronic unpredictable mild stress (CUMS). 
      STUDY DESIGN: Antidepressant-like effects of ZZHPD were investigated through 
      behavioral tests, and potential mechanism was assessed by neuroendocrine system, 
      neurotrophin and hippocampal neurogenesis. METHODS: Antidepressant-like effects 
      of ZZHPD (3.66, 7.32 and 14.64 g/kg/day) were estimated through coat state test, 
      sucrose preference test, forced swimming test and open-field test. Effects of 
      ZZHPD on hypothalamic-pituitary-adrenal (HPA) axis were evaluated by hormones 
      measurement and dexamethasone suppression test. In addition, the expression of 
      brain-derived neurotrophic factor (BDNF) in hippocampus was measured, as well as 
      hippocampal neurogenesis was investigated by doublecortin (DCX) and 
      5-bromo-2-deoxyuridine/neuronal nuclei (BrdU/NeuN). RESULTS: The results 
      demonstrated that ZZHPD significantly reversed the depressive-like behaviors, 
      normalized the levels of adrenocorticotropic hormone (ACTH) and corticosterone 
      (CORT), restored the negative feedback loop of HPA axis and improved the levels 
      of BDNF, DCX and BrdU/NeuN compared with those in CUMS-induced rats. CONCLUSION: 
      The above results revealed that ZZHPD exerted antidepressant-like effects 
      possibly by normalizing HPA axis function, increasing expression of BDNF in 
      hippocampus and promoting hippocampal neurogenesis.
CI  - Copyright (c) 2015 Elsevier GmbH. All rights reserved.
FAU - Xing, Hang
AU  - Xing H
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 
      110016, China.
FAU - Zhang, Kuo
AU  - Zhang K
AD  - Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, 
      Shenyang 110016, China.
FAU - Zhang, Ruowen
AU  - Zhang R
AD  - Stem Cell Institute, Department of Biochemistry and Molecular Genetics, 
      University of Alabama at Birmingham, Shelby Interdisciplinary Biomedical 
      Building, Room 777, 1825 University Blvd, Birmingham, AL 35294-0024, USA.
FAU - Shi, Huiyan
AU  - Shi H
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 
      110016, China.
FAU - Bi, Kaishun
AU  - Bi K
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 
      110016, China.
FAU - Chen, Xiaohui
AU  - Chen X
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 
      110016, China. Electronic address: cxh_syphu@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20151116
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Iridoids)
RN  - 0 (Plant Extracts)
RN  - 0 (Zhi-Zi-Hou-Pu decoction)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Antidepressive Agents/isolation & purification/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Citrus/chemistry
MH  - Corticosterone/blood
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Doublecortin Protein
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Fruit/chemistry
MH  - Gardenia/chemistry
MH  - Hippocampus/drug effects
MH  - Hypothalamo-Hypophyseal System/drug effects
MH  - Iridoids/*pharmacology
MH  - Magnolia/chemistry
MH  - Male
MH  - Molecular Structure
MH  - Neurogenesis/drug effects
MH  - Pituitary-Adrenal System/drug effects
MH  - Plant Bark/chemistry
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Stress, Psychological
OTO - NOTNLM
OT  - Antidepressant
OT  - Chronic unpredictable mild stress
OT  - Hippocampal neurogenesis
OT  - Hypothalamic-pituitary-adrenal axis
OT  - Water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium 
      and Magnolia officinalis
EDAT- 2015/11/26 06:00
MHDA- 2016/01/12 06:00
CRDT- 2015/11/25 06:00
PHST- 2015/06/10 00:00 [received]
PHST- 2015/09/11 00:00 [revised]
PHST- 2015/09/15 00:00 [accepted]
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/01/12 06:00 [medline]
AID - S0944-7113(15)00280-9 [pii]
AID - 10.1016/j.phymed.2015.09.004 [doi]
PST - ppublish
SO  - Phytomedicine. 2015 Dec 1;22(13):1178-85. doi: 10.1016/j.phymed.2015.09.004. Epub 
      2015 Nov 16.