PMID- 26598919
OWN - NLM
STAT- MEDLINE
DCOM- 20160111
LR  - 20151125
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 22
IP  - 13
DP  - 2015 Dec 1
TI  - Antitussive effect of a fixed combination of Justicia adhatoda, Echinacea 
      purpurea and Eleutherococcus senticosus extracts in patients with acute upper 
      respiratory tract infection: A comparative, randomized, double-blind, 
      placebo-controlled study.
PG  - 1195-200
LID - S0944-7113(15)00303-7 [pii]
LID - 10.1016/j.phymed.2015.10.001 [doi]
AB  - BACKGROUND: Kan Jang(R) oral solution (KJ) is a fixed combination of aqueous 
      ethanolic extracts of Justicia adhatoda L. leaf, Echinacea purpurea (L.) Moench 
      root, and Eleutherococcus senticosus (Rupr. & Maxim.) Harms root. It is approved 
      in Scandinavia as an herbal medicinal product for respiratory tract infection 
      treatment. PURPOSE: The present clinical trial aimed to compare the antitussive 
      effect of KJ with placebo (PL) and bromhexine (BH) among patients of 18-65 years 
      old with non-complicated upper respiratory infections (URI; i.e., common cold). 
      STUDY DESIGN: We performed a parallel-group, randomized, double-blinded, 
      placebo-controlled trial in in 177 patients with acute URI over a 5 day period. 
      METHODS: We investigated the antitussive effects of a KJ (30 ml/day; 762 mg 
      genuine extracts with standardized contents of 0.2 mg/ml vasicine, 0.8 mg/ml 
      chicoric acid, and 0.03 mg/ml eleutherosides B and E), bromhexine hydrochloride 
      (24 mg/30 ml/day) and PL on cough and blood markers. The primary outcome was 
      cough relief, which was assessed as the change of cough frequency from baseline 
      (cough index). Secondary outcomes were safety with regards to reported adverse 
      events (AEs) and hematological data. RESULTS: Both KJ and BH relieved cough more 
      effectively than placebo. On the third and fourth days of treatment, we observed 
      faster improvement in the group receiving KJ compared to in the groups receiving 
      BH (100%) or PL (100%), indicating a slightly shorter recovery time in the KJ 
      group. KJ showed a good tolerability and safety profile. CONCLUSION: KJ exerted 
      significant antitussive effects in URI. The present data further support the 
      therapeutic use of KJ in upper respiratory tract infections.
CI  - Copyright (c) 2015 The Authors. Published by Elsevier GmbH.. All rights reserved.
FAU - Barth, Anders
AU  - Barth A
AD  - Partus Kvinnohalsa, Sodra v. 2, 412 54, Goteborg.
FAU - Hovhannisyan, Areg
AU  - Hovhannisyan A
AD  - Anti-doping Service of Republican Centre of Sport Medicine, Acharyan Street, 2/6, 
      Yerevan, Armenia . Electronic address: areg@armnado.am.
FAU - Jamalyan, Kristina
AU  - Jamalyan K
AD  - Yerevan State Medical University of Armenia, Koryun 2 0025, Yerevan, Armenia.
FAU - Narimanyan, Mikael
AU  - Narimanyan M
AD  - Yerevan State Medical University of Armenia, Koryun 2 0025, Yerevan, Armenia.
LA  - eng
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20151021
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Antitussive Agents)
RN  - 0 (Plant Extracts)
RN  - Q1J152VB1P (Bromhexine)
SB  - IM
MH  - Adult
MH  - Antitussive Agents/*therapeutic use
MH  - Bromhexine/therapeutic use
MH  - Common Cold/drug therapy
MH  - Cough/*drug therapy
MH  - Double-Blind Method
MH  - Echinacea/chemistry
MH  - Eleutherococcus/chemistry
MH  - Female
MH  - Humans
MH  - Justicia/chemistry
MH  - Male
MH  - Middle Aged
MH  - *Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - Plant Leaves/chemistry
MH  - Plant Roots/chemistry
MH  - Respiratory Tract Infections/*drug therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Cough
OT  - Kan Jang
OT  - Randomized controlled trial
EDAT- 2015/11/26 06:00
MHDA- 2016/01/12 06:00
CRDT- 2015/11/25 06:00
PHST- 2015/08/20 00:00 [received]
PHST- 2015/10/02 00:00 [revised]
PHST- 2015/10/04 00:00 [accepted]
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/01/12 06:00 [medline]
AID - S0944-7113(15)00303-7 [pii]
AID - 10.1016/j.phymed.2015.10.001 [doi]
PST - ppublish
SO  - Phytomedicine. 2015 Dec 1;22(13):1195-200. doi: 10.1016/j.phymed.2015.10.001. 
      Epub 2015 Oct 21.