PMID- 26601018
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151125
LR  - 20220201
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 6
IP  - 11
DP  - 2015 Nov 1
TI  - High-speed intravascular photoacoustic imaging at 1.7 mum with a KTP-based OPO.
PG  - 4557-66
LID - 10.1364/BOE.6.004557 [doi]
AB  - Lipid deposition inside the arterial wall is a hallmark of plaque vulnerability. 
      Based on overtone absorption of C-H bonds, intravascular photoacoustic (IVPA) 
      catheter is a promising technology for quantifying the amount of lipid and its 
      spatial distribution inside the arterial wall. Thus far, the clinical translation 
      of IVPA technology is limited by its slow imaging speed due to lack of a 
      high-pulse-energy high-repetition-rate laser source for lipid-specific first 
      overtone excitation at 1.7 mum. Here, we demonstrate a potassium titanyl phosphate 
      (KTP)-based optical parametric oscillator with output pulse energy up to 2 mJ at 
      a wavelength of 1724 nm and with a repetition rate of 500 Hz. Using this laser 
      and a ring-shape transducer, IVPA imaging at speed of 1 frame per sec was 
      demonstrated. Performance of the IVPA imaging system's resolution, sensitivity, 
      and specificity were characterized by carbon fiber and a lipid-mimicking phantom. 
      The clinical utility of this technology was further evaluated ex vivo in an 
      excised atherosclerotic human femoral artery with comparison to histology.
FAU - Hui, Jie
AU  - Hui J
AD  - Department of Physics and Astronomy, Purdue University, West Lafayette, IN, 
      47906, USA ; These authors contributed equally to this work.
FAU - Yu, Qianhuan
AU  - Yu Q
AD  - Key Laboratory of Space Laser Communication and Detection Technology, Shanghai 
      Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 
      201800, China ; University of Chinese Academy of Science, Beijing 100049, China ; 
      These authors contributed equally to this work.
FAU - Ma, Teng
AU  - Ma T
AD  - Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, 
      University of Southern California, Los Angeles, CA, 90089, USA ; These authors 
      contributed equally to this work.
FAU - Wang, Pu
AU  - Wang P
AD  - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 
      47906, USA.
FAU - Cao, Yingchun
AU  - Cao Y
AD  - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 
      47906, USA.
FAU - Bruning, Rebecca S
AU  - Bruning RS
AD  - Department of Cellular & Integrative Physiology, Indiana University School of 
      Medicine, Indianapolis, IN, 46202, USA.
FAU - Qu, Yueqiao
AU  - Qu Y
AD  - Department of Biomedical Engineering, University of California, Irvine, Irvine, 
      CA, 92612, USA.
FAU - Chen, Zhongping
AU  - Chen Z
AD  - Department of Biomedical Engineering, University of California, Irvine, Irvine, 
      CA, 92612, USA.
FAU - Zhou, Qifa
AU  - Zhou Q
AD  - Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, 
      University of Southern California, Los Angeles, CA, 90089, USA.
FAU - Sturek, Michael
AU  - Sturek M
AD  - Department of Cellular & Integrative Physiology, Indiana University School of 
      Medicine, Indianapolis, IN, 46202, USA.
FAU - Cheng, Ji-Xin
AU  - Cheng JX
AD  - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 
      47906, USA ; jcheng@purdue.edu.
FAU - Chen, Weibiao
AU  - Chen W
AD  - Key Laboratory of Space Laser Communication and Detection Technology, Shanghai 
      Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 
      201800, China ; wbchen@mail.shcnc.ac.cn.
LA  - eng
GR  - R01 HL125385/HL/NHLBI NIH HHS/United States
GR  - R01 HL127271/HL/NHLBI NIH HHS/United States
GR  - T32 HL079995/HL/NHLBI NIH HHS/United States
GR  - T32 HL116270/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20151023
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC4646562
OTO - NOTNLM
OT  - (110.0110) Imaging systems
OT  - (110.5125) Photoacoustics
OT  - (140.3460) Lasers
OT  - (170.1610) Clinical applications
OT  - (170.5120) Photoacoustic imaging
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/10/23
CRDT- 2015/11/25 06:00
PHST- 2015/09/21 00:00 [received]
PHST- 2015/10/18 00:00 [revised]
PHST- 2015/10/19 00:00 [accepted]
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/10/23 00:00 [pmc-release]
AID - 250606 [pii]
AID - 10.1364/BOE.6.004557 [doi]
PST - epublish
SO  - Biomed Opt Express. 2015 Oct 23;6(11):4557-66. doi: 10.1364/BOE.6.004557. 
      eCollection 2015 Nov 1.