PMID- 26601091
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151125
LR  - 20240324
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 4
DP  - 2015
TI  - Effects of doxepin on brain-derived neurotrophic factor, tumor necrosis factor 
      alpha, mitogen-activated protein kinase 14, and AKT1 genes expression in rat 
      hippocampus.
PG  - 203
LID - 10.4103/2277-9175.166139 [doi]
LID - 203
AB  - BACKGROUND: It has been suggested that doxepin in addition to enhancement of 
      noradrenaline and serotonin levels may have neuroprotective effects. Therefore, 
      this study investigated the effect of doxepin on gene expression of brain-derived 
      neurotrophic factor (BDNF), tumor necrosis factor alpha (TNF-alpha), 
      mitogen-activated protein kinase 14 (MAPK14), and serine-threonine protein kinase 
      AKT1 in rat hippocampus. MATERIALS AND METHODS: Male rats were divided randomly 
      into three groups: Control, doxepin 1 mg/kg, and doxepin 5 mg/kg. Rats received 
      an i.p injection of doxepin for 21 days. Then the hippocampi were dissected for 
      the measurement of the expression of BDNF, TNF-alpha, MAPK14, and AKT1 genes. 
      RESULTS: Our results showed no significant effects of doxepin on gene expression 
      of BDNF, TNF-alpha, MAPK14, and AKT1 genes in the hippocampus. CONCLUSIONS: These 
      results did not show significant effects of doxepin on the genes that affect the 
      neuronal survival in intact animals. However, more studies need to be done, 
      especially in models associated with neuronal damage.
FAU - Eidelkhani, Nastaran
AU  - Eidelkhani N
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Radahmadi, Maryam
AU  - Radahmadi M
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Kazemi, Mohammad
AU  - Kazemi M
AD  - Department of Genetics and Molecular Biology, School of Medicine, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Rafiee, Laleh
AU  - Rafiee L
AD  - Applied Physiology Research Center, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Alaei, Hojjatallah
AU  - Alaei H
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Reisi, Parham
AU  - Reisi P
AD  - Department of Physiology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran ; Department of Genetics and Molecular Biology, School of 
      Medicine, Isfahan University of Medical Sciences, Isfahan, Iran ; Biosensor 
      Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20150928
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC4620617
OTO - NOTNLM
OT  - AKT1
OT  - brain-derived neurotrophic factor
OT  - doxepin
OT  - hippocampus
OT  - mitogen-activated protein kinase 14
OT  - tumor necrosis factor alpha
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/09/28
CRDT- 2015/11/25 06:00
PHST- 2015/05/30 00:00 [received]
PHST- 2015/06/28 00:00 [accepted]
PHST- 2015/11/25 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/09/28 00:00 [pmc-release]
AID - ABR-4-203 [pii]
AID - 10.4103/2277-9175.166139 [doi]
PST - epublish
SO  - Adv Biomed Res. 2015 Sep 28;4:203. doi: 10.4103/2277-9175.166139. eCollection 
      2015.