PMID- 26602146
OWN - NLM
STAT- MEDLINE
DCOM- 20161107
LR  - 20161230
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 77
IP  - 2
DP  - 2016 Feb
TI  - Effect of major histocompatibility complex haplotype matching by C4 and MICA 
      genotyping on acute graft versus host disease in unrelated hematopoietic stem 
      cell transplantation.
PG  - 176-83
LID - S0198-8859(15)00576-5 [pii]
LID - 10.1016/j.humimm.2015.11.015 [doi]
AB  - We explored whether matching of human leukocyte antigen (HLA) haplotypes between 
      the recipient and donor of hematopoietic stem cell transplantation (HSCT) 
      predicted by C4 and MICA typing is associated with the incidence of acute graft 
      versus host disease (aGVHD). DNA preparations collected from a total of 81 
      recipient and donor pairs were used for PCR-based C4 subtyping and/or MICA 
      sequence-based typing. Incidences of aGVHD were compared according to C4 and MICA 
      matching. The six most common MICA alleles were MICA*008:01, *010:01, *002:01, 
      *004, *009:01/049, and *012:01. Among the 59 unrelated pairs, HLA alleles were 
      matched in 34 (57.6%). C4 subtypes were identical between the recipient and donor 
      in 28 (82.4%) HLA-matched unrelated pairs, while MICA genotypes were matched in 
      all HLA-matched unrelated pairs. In the 22 HLA-matched related pairs, all 
      recipients showed identical C4 subtypes with their respective donors. In 
      multivariate analysis, C4 mismatch was a significant risk factor associated with 
      the development of aGVHD in unrelated HSCT (hazard ratio=3.24, P=0.006). 
      PCR-based C4 subtyping is a simple method for assessing the genetic identity of 
      the HLA region between a recipient and unrelated donor. This test would be also 
      useful for prediction of aGVHD in HSCT.
CI  - Copyright (c) 2015 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Park, Yongjung
AU  - Park Y
AD  - Department of Laboratory Medicine, National Health Insurance Service Ilsan 
      Hospital, Goyang, Republic of Korea.
FAU - Cheong, June-Won
AU  - Cheong JW
AD  - Division of Hematology, Department of Internal Medicine, Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Republic of Korea.
FAU - Park, Myoung Hee
AU  - Park MH
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea; Korea Organ Donation Agency Laboratory, Seoul, Republic 
      of Korea.
FAU - Kim, Myoung Soo
AU  - Kim MS
AD  - Division of Transplantation Surgery, Department of Surgery, Severance Hospital, 
      Yonsei University College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Jong Sun
AU  - Kim JS
AD  - Department of Microbiology, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kim, Hyon-Suk
AU  - Kim HS
AD  - Department of Laboratory Medicine, Severance Hospital, Yonsei University College 
      of Medicine, Seoul, Republic of Korea. Electronic address: kimhs54@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151118
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Complement C4)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Complement C4/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Graft vs Host Disease/*genetics/immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility/genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Polymorphism, Genetic
MH  - Young Adult
OTO - NOTNLM
OT  - C4 gene
OT  - Graft versus host disease
OT  - Hematopoietic stem cell transplantation
OT  - Human leukocyte antigen
OT  - MHC class I polypeptide-related sequence A
EDAT- 2015/11/26 06:00
MHDA- 2016/11/08 06:00
CRDT- 2015/11/26 06:00
PHST- 2015/09/14 00:00 [received]
PHST- 2015/11/05 00:00 [revised]
PHST- 2015/11/17 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/11/08 06:00 [medline]
AID - S0198-8859(15)00576-5 [pii]
AID - 10.1016/j.humimm.2015.11.015 [doi]
PST - ppublish
SO  - Hum Immunol. 2016 Feb;77(2):176-83. doi: 10.1016/j.humimm.2015.11.015. Epub 2015 
      Nov 18.