PMID- 26602436
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20211203
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 43
IP  - 4
DP  - 2016 Aug
TI  - Aberrant Kif2a and Ki67 expression predicts poor survival in laryngeal squamous 
      cell carcinoma.
PG  - 433-9
LID - S0385-8146(15)00237-0 [pii]
LID - 10.1016/j.anl.2015.10.012 [doi]
AB  - OBJECTIVE: Previous studies have demonstrated that aberrant Kif2a expression is 
      associated with tumor aggressiveness and poor prognosis in various human cancers. 
      However, the clinicopathological significance of Kif2a in laryngeal squamous cell 
      carcinoma (LSCC) is unknown. The aim of this study is to analyze the prognostic 
      significance of Kif2a, alone and in combination with Ki67 protein expression, in 
      LSCC patients. METHODS: We examined the expression status of Kif2a and Ki67 
      protein in 165 laryngeal tissues (137 primary tumors and 28 cases of matched 
      normal surgical margins) by immunohistochemistry (IHC) analysis using tissue 
      microarrays. RESULTS: We found that expression correlated with clinical 
      parameters and overall survival (OS). Our results revealed that Kif2a and Ki67 
      protein expression was significantly higher in cancerous tissues compared to 
      normal surgical margins. High Kif2a protein expression (Kif2a+) was significantly 
      associated with tumor stage (P=0.026) and cervical lymph node metastasis 
      (P=0.034). A significant correlation between Kif2a and Ki67 protein expression 
      was observed (P=0.040). Multivariate analysis revealed that patients with Kif2a+ 
      (hazard ratio [HR] 3.640, 95% confidence interval [CI] 1.253-10.570; P=0.018) and 
      high Ki67 (Ki67+) expression (HR 3.086, 95%CI 1.016-9.371; P=0.047) had poor OS. 
      CONCLUSION: We speculate that Kif2a and Ki67 can be used as prognostic markers 
      for LSCC patients.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhang, Qicheng
AU  - Zhang Q
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of 
      Nantong University, Nantong, Jiangsu Province, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of 
      Nantong University, Nantong, Jiangsu Province, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of 
      Nantong University, Nantong, Jiangsu Province, China.
FAU - Xu, Hongli
AU  - Xu H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Third People's 
      Hospital of Nantong, Nantong, Jiangsu Province, China.
FAU - You, Yiwen
AU  - You Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of 
      Nantong University, Nantong, Jiangsu Province, China. Electronic address: 
      xuhonglimm@163.com.
LA  - eng
PT  - Journal Article
DEP - 20151118
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (KIF2A protein, human)
RN  - 0 (Ki-67 Antigen)
RN  - EC 3.6.4.4 (Kinesins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/mortality/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/*metabolism
MH  - Kinesins/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Survival Rate
MH  - Tissue Array Analysis
OTO - NOTNLM
OT  - Ki67
OT  - Kif2a
OT  - Laryngeal squamous cell carcinoma
OT  - Prognosis
OT  - Tissue microarrays
EDAT- 2015/11/26 06:00
MHDA- 2017/02/28 06:00
CRDT- 2015/11/26 06:00
PHST- 2015/08/22 00:00 [received]
PHST- 2015/10/17 00:00 [revised]
PHST- 2015/10/20 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
AID - S0385-8146(15)00237-0 [pii]
AID - 10.1016/j.anl.2015.10.012 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2016 Aug;43(4):433-9. doi: 10.1016/j.anl.2015.10.012. Epub 
      2015 Nov 18.