PMID- 26602762
OWN - NLM
STAT- MEDLINE
DCOM- 20160919
LR  - 20181113
IS  - 1471-499X (Electronic)
IS  - 1471-4914 (Print)
IS  - 1471-4914 (Linking)
VI  - 21
IP  - 12
DP  - 2015 Dec
TI  - Variability in Humoral Immunity to Measles Vaccine: New Developments.
PG  - 789-801
LID - S1471-4914(15)00195-1 [pii]
LID - 10.1016/j.molmed.2015.10.005 [doi]
AB  - Despite the existence of an effective measles vaccine, resurgence in measles 
      cases in the USA and across Europe has occurred, including in individuals 
      vaccinated with two doses of the vaccine. Host genetic factors result in 
      inter-individual variation in measles vaccine-induced antibodies, and play a role 
      in vaccine failure. Studies have identified HLA (human leukocyte antigen) and 
      non-HLA genetic influences that individually or jointly contribute to the 
      observed variability in the humoral response to vaccination among healthy 
      individuals. In this exciting era, new high-dimensional approaches and techniques 
      including vaccinomics, systems biology, GWAS, epitope prediction and 
      sophisticated bioinformatics/statistical algorithms provide powerful tools to 
      investigate immune response mechanisms to the measles vaccine. These might 
      predict, on an individual basis, outcomes of acquired immunity post measles 
      vaccination.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Haralambieva, Iana H
AU  - Haralambieva IH
AD  - Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA; Mayo 
      Clinic Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, 
      USA.
FAU - Kennedy, Richard B
AU  - Kennedy RB
AD  - Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA; Mayo 
      Clinic Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, 
      USA.
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
AD  - Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA; Mayo 
      Clinic Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, 
      USA.
FAU - Whitaker, Jennifer A
AU  - Whitaker JA
AD  - Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA; Mayo 
      Clinic Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, 
      USA; Mayo Clinic Division of Infectious Diseases, Mayo Clinic, Rochester, MN 
      55905, USA.
FAU - Poland, Gregory A
AU  - Poland GA
AD  - Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA; Mayo 
      Clinic Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, 
      USA. Electronic address: poland.gregory@mayo.edu.
LA  - eng
GR  - R01 AI033144/AI/NIAID NIH HHS/United States
GR  - AI033144/AI/NIAID NIH HHS/United States
GR  - R01 AI048793/AI/NIAID NIH HHS/United States
GR  - R37 AI048793/AI/NIAID NIH HHS/United States
GR  - R37AI048793/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20151118
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - 0 (HLA Antigens)
RN  - 0 (Measles Vaccine)
SB  - IM
MH  - Developed Countries
MH  - Genetic Association Studies
MH  - HLA Antigens/immunology
MH  - Humans
MH  - *Immunity, Humoral
MH  - Measles Vaccine/*immunology
MH  - Vaccination
PMC - PMC4679650
MID - NIHMS739658
COIS- Conflict of Interest Dr. Poland is the chair of a Safety Evaluation Committee for 
      novel investigational vaccine trials being conducted by Merck Research 
      Laboratories. Dr. Poland offers consultative advice on vaccine development to 
      Merck & Co. Inc., CSL Biotherapies, Avianax, Dynavax, Novartis Vaccines and 
      Therapeutics, Emergent Biosolutions, Adjuvance, and Microdermis. Drs. Poland and 
      Ovsyannikova hold two patents related to vaccinia and measles peptide research. 
      These activities have been reviewed by the Mayo Clinic Conflict of Interest 
      Review Board and are conducted in compliance with Mayo Clinic Conflict of 
      Interest policies. This research has been reviewed by the Mayo Clinic Conflict of 
      Interest Review Board and was conducted in compliance with Mayo Clinic Conflict 
      of Interest policies.
EDAT- 2015/11/26 06:00
MHDA- 2016/09/20 06:00
PMCR- 2016/12/01
CRDT- 2015/11/26 06:00
PHST- 2015/08/17 00:00 [received]
PHST- 2015/10/20 00:00 [revised]
PHST- 2015/10/21 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/09/20 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - S1471-4914(15)00195-1 [pii]
AID - 10.1016/j.molmed.2015.10.005 [doi]
PST - ppublish
SO  - Trends Mol Med. 2015 Dec;21(12):789-801. doi: 10.1016/j.molmed.2015.10.005. Epub 
      2015 Nov 18.