PMID- 26603404
OWN - NLM
STAT- MEDLINE
DCOM- 20160622
LR  - 20151125
IS  - 1873-4502 (Electronic)
IS  - 0886-3350 (Linking)
VI  - 41
IP  - 9
DP  - 2015 Sep
TI  - Dexamethasone implant as an effective treatment option for macular edema due to 
      Irvine-Gass syndrome.
PG  - 1954-61
LID - S0886-3350(15)01099-8 [pii]
LID - 10.1016/j.jcrs.2015.10.025 [doi]
AB  - PURPOSE: To investigate the effectiveness and safety of a dexamethasone implant 
      (Ozurdex) to treat pseudophakic macular edema (Irvine-Gass syndrome). SETTING: 
      Department of Ophthalmology, Ludwig-Maximilians-University Munich, Munich, 
      Germany. DESIGN: Prospective nonrandomized study. METHODS: Preoperatively and in 
      12 monthly postoperative intervals, a complete ophthalmic examination was 
      performed in study patients, including measurement of corrected distance visual 
      acuity (CDVA) using the standard Early Treatment Diabetic Retinopathy Study 
      chart, intraocular pressure, foveal thickness using spectral-domain optical 
      coherence tomography (SD-OCT), and retinal sensitivity (mean defect depth) using 
      microperimetry. Morphological aspects of the inner segment-outer segment junction 
      and visual function were correlated. RESULTS: Twenty-three eyes (23 patients) 
      with pseudophakic macular edema after uneventful cataract surgery were included. 
      The mean duration of macular edema before treatment with a dexamethasone implant 
      was 5.4 months (range 2 to 8 months). The CDVA increased in all patients from 
      30.2 letters +/- 4.3 (SD) at baseline to 50.4 +/- 4.9 letters at 12 months (P = 
      .0016), regardless of the time of macular edema duration. Foveal thickness 
      decreased from 520.8 +/- 71.4 mum to 232.7 +/- 26.6 mum (P < .002). Retinal sensitivity 
      (mean defect depth) increased significantly over a 12-month follow-up, 
      correlating positively with a restored inner segment-outer segment junction on 
      SD-OCT analyses. No relevant adverse events were reported, and 9 recurrences 
      occurred with a peak after 3 months and required a second dexamethasone implant 
      injection. CONCLUSION: The dexamethasone implant was safe and effective in 
      treating pseudophakic macular edema regardless of the duration of the edema. 
      FINANCIAL DISCLOSURE: Drs. Mayer and Haritoglou are consultants to Allergan, Inc. 
      No author has a financial or proprietary interest in any material or method 
      mentioned.
CI  - Copyright (c) 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
FAU - Mayer, Wolfgang J
AU  - Mayer WJ
AD  - From the Department of Ophthalmology (Mayer, Kurz, Wolf, Kook, Kreutzer, Kampik, 
      Priglinger, Haritoglou), Ludwig-Maximilians-University, and Herzog Carl Theodor 
      Eye Clinic (Haritoglou), Munich, Germany; the Department of Ophthalmology 
      (Kreutzer, Priglinger), Allgemeines Krankenhaus Linz, Linz, Austria. Electronic 
      address: wolfgang.j.mayer@med.uni-muenchen.de.
FAU - Kurz, Stefanie
AU  - Kurz S
AD  - From the Department of Ophthalmology (Mayer, Kurz, Wolf, Kook, Kreutzer, Kampik, 
      Priglinger, Haritoglou), Ludwig-Maximilians-University, and Herzog Carl Theodor 
      Eye Clinic (Haritoglou), Munich, Germany; the Department of Ophthalmology 
      (Kreutzer, Priglinger), Allgemeines Krankenhaus Linz, Linz, Austria.
FAU - Wolf, Armin
AU  - Wolf A
AD  - From the Department of Ophthalmology (Mayer, Kurz, Wolf, Kook, Kreutzer, Kampik, 
      Priglinger, Haritoglou), Ludwig-Maximilians-University, and Herzog Carl Theodor 
      Eye Clinic (Haritoglou), Munich, Germany; the Department of Ophthalmology 
      (Kreutzer, Priglinger), Allgemeines Krankenhaus Linz, Linz, Austria.
FAU - Kook, Daniel
AU  - Kook D
AD  - From the Department of Ophthalmology (Mayer, Kurz, Wolf, Kook, Kreutzer, Kampik, 
      Priglinger, Haritoglou), Ludwig-Maximilians-University, and Herzog Carl Theodor 
      Eye Clinic (Haritoglou), Munich, Germany; the Department of Ophthalmology 
      (Kreutzer, Priglinger), Allgemeines Krankenhaus Linz, Linz, Austria.
FAU - Kreutzer, Thomas
AU  - Kreutzer T
AD  - From the Department of Ophthalmology (Mayer, Kurz, Wolf, Kook, Kreutzer, Kampik, 
      Priglinger, Haritoglou), Ludwig-Maximilians-University, and Herzog Carl Theodor 
      Eye Clinic (Haritoglou), Munich, Germany; the Department of Ophthalmology 
      (Kreutzer, Priglinger), Allgemeines Krankenhaus Linz, Linz, Austria.
FAU - Kampik, Anselm
AU  - Kampik A
AD  - From the Department of Ophthalmology (Mayer, Kurz, Wolf, Kook, Kreutzer, Kampik, 
      Priglinger, Haritoglou), Ludwig-Maximilians-University, and Herzog Carl Theodor 
      Eye Clinic (Haritoglou), Munich, Germany; the Department of Ophthalmology 
      (Kreutzer, Priglinger), Allgemeines Krankenhaus Linz, Linz, Austria.
FAU - Priglinger, Siegfried
AU  - Priglinger S
AD  - From the Department of Ophthalmology (Mayer, Kurz, Wolf, Kook, Kreutzer, Kampik, 
      Priglinger, Haritoglou), Ludwig-Maximilians-University, and Herzog Carl Theodor 
      Eye Clinic (Haritoglou), Munich, Germany; the Department of Ophthalmology 
      (Kreutzer, Priglinger), Allgemeines Krankenhaus Linz, Linz, Austria.
FAU - Haritoglou, Christos
AU  - Haritoglou C
AD  - From the Department of Ophthalmology (Mayer, Kurz, Wolf, Kook, Kreutzer, Kampik, 
      Priglinger, Haritoglou), Ludwig-Maximilians-University, and Herzog Carl Theodor 
      Eye Clinic (Haritoglou), Munich, Germany; the Department of Ophthalmology 
      (Kreutzer, Priglinger), Allgemeines Krankenhaus Linz, Linz, Austria.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
RN  - 0 (Drug Implants)
RN  - 0 (Glucocorticoids)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
CIN - J Cataract Refract Surg. 2016 Apr;42(4):648. PMID: 27113900
MH  - Aged
MH  - Aged, 80 and over
MH  - Dexamethasone/*administration & dosage
MH  - Drug Implants
MH  - Female
MH  - Glucocorticoids/*administration & dosage
MH  - Humans
MH  - Intravitreal Injections
MH  - Macular Edema/*drug therapy/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pseudophakia/etiology
MH  - Retina/physiology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2015/11/26 06:00
MHDA- 2016/06/23 06:00
CRDT- 2015/11/26 06:00
PHST- 2014/10/14 00:00 [received]
PHST- 2015/01/10 00:00 [revised]
PHST- 2015/01/13 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/06/23 06:00 [medline]
AID - S0886-3350(15)01099-8 [pii]
AID - 10.1016/j.jcrs.2015.10.025 [doi]
PST - ppublish
SO  - J Cataract Refract Surg. 2015 Sep;41(9):1954-61. doi: 10.1016/j.jcrs.2015.10.025.