PMID- 26603459
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151125
LR  - 20181113
IS  - 2051-817X (Print)
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 3
IP  - 11
DP  - 2015 Nov
TI  - Role of brain-derived neurotrophic factor in the excitatory-inhibitory imbalance 
      during the critical period of postnatal respiratory development in the rat.
LID - 10.14814/phy2.12631 [doi]
LID - e12631
AB  - The critical period of respiratory development in rats is a narrow window toward 
      the end of the second postnatal week (P12-13), when abrupt neurochemical, 
      electrophysiological, and ventilatory changes occur, when inhibition dominates 
      over excitation, and when the animals' response to hypoxia is the weakest. The 
      goal of this study was to further test our hypothesis that a major mechanism 
      underlying the synaptic imbalance during the critical period is a reduced 
      expression of brain-derived neurotrophic factor (BDNF) and its TrkB receptors. 
      Our aims were to determine (1) that the inhibitory dominance observed in 
      hypoglossal motoneurons during the critical period was also demonstrable in a key 
      respiratory chemosensor, NTSVL; (2) if in vivo application of a TrkB agonist, 
      7,8-DHF, would prevent, but a TrkB antagonist, ANA-12, would accentuate the 
      synaptic imbalance; and (3) if hypoxia would also heighten the imbalance. Our 
      results indicate that (1) the synaptic imbalance was evident in the NTSVL during 
      the critical period; (2) intraperitoneal injections of 7,8-DHF prevented the 
      synaptic imbalance during the critical period, whereas ANA-12 in vivo accentuated 
      such an imbalance; and (3) acute hypoxia induced the weakest response in both the 
      amplitude and frequency of sEPSCs during the critical period, but it increased 
      the frequency of sIPSCs during the critical period. Thus, our findings are 
      consistent with and strengthen our hypothesis that BDNF and TrkB play a 
      significant role in inducing a synaptic imbalance during the critical period of 
      respiratory development in the rat.
CI  - (c) 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on 
      behalf of the American Physiological Society and The Physiological Society.
FAU - Gao, Xiu-Ping
AU  - Gao XP
AD  - Department of Cell Biology, Neurobiology and Anatomy, Medical College of 
      Wisconsin, Milwaukee, Wisconsin.
FAU - Zhang, Hanmeng
AU  - Zhang H
AD  - Department of Cell Biology, Neurobiology and Anatomy, Medical College of 
      Wisconsin, Milwaukee, Wisconsin.
FAU - Wong-Riley, Margaret
AU  - Wong-Riley M
AD  - Department of Cell Biology, Neurobiology and Anatomy, Medical College of 
      Wisconsin, Milwaukee, Wisconsin mwr@mcw.edu.
LA  - eng
PT  - Journal Article
DEP - 20151124
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
EIN - Physiol Rep. 2016 Jun;4(11). pii: e12842. doi: 10.14814/phy2.12842. PMID: 
      27302993
PMC - PMC4673652
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - NTSVL
OT  - TrkB
OT  - critical period
OT  - hypoglossal motoneurons
OT  - hypoxia
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/11/24
CRDT- 2015/11/26 06:00
PHST- 2015/08/21 00:00 [received]
PHST- 2015/10/26 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/11/24 00:00 [pmc-release]
AID - 3/11/e12631 [pii]
AID - 10.14814/phy2.12631 [doi]
PST - ppublish
SO  - Physiol Rep. 2015 Nov;3(11):e12631. doi: 10.14814/phy2.12631. Epub 2015 Nov 24.