PMID- 26603468
OWN - NLM
STAT- MEDLINE
DCOM- 20161102
LR  - 20221207
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 170
IP  - 1
DP  - 2016 Jan
TI  - BDNF polymorphisms are associated with schizophrenia onset and positive symptoms.
PG  - 41-7
LID - S0920-9964(15)30052-9 [pii]
LID - 10.1016/j.schres.2015.11.009 [doi]
AB  - Numerous studies have showed that brain-derived neurotrophic factor (BDNF) may be 
      involved in the pathogenesis and pathophysiology of schizophrenia. The purposes 
      of this study were to investigate the potential association of BDNF gene 
      polymorphisms with susceptibility to schizophrenia and the psychopathological 
      symptoms in patients with schizophrenia in a Han Chinese population. Four 
      polymorphisms (rs6265, rs12273539, rs10835210 and rs2030324) of the BDNF gene 
      were analyzed in a case-control study of 1887 Han Chinese individuals (844 
      patients and 1043 controls). We assessed 825 patients for psychopathology using 
      the Positive and Negative Syndrome Scale. In single marker analyses the BDNF 
      rs10835210 mutant A allele was significantly associated with schizophrenia. 
      Haplotype analyses revealed higher frequencies of haplotypes containing the 
      mutant A allele of the rs10835210 in schizophrenia than controls. We also found 
      that this polymorphism rs10835210 was associated with positive symptoms, and the 
      patients carrying the mutational allele A showed more positive symptoms. These 
      findings suggest the role of these BDNF gene variants in both susceptibility to 
      schizophrenia and in clinical symptom severity.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Zhang, Xiang Yang
AU  - Zhang XY
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China; Department of Psychiatry and Behavioral Sciences, Harris County 
      Psychiatric Center, The University of Texas Health Science Center at Houston, 
      Houston, TX, USA. Electronic address: xiang.y.zhang@uth.tmc.edu.
FAU - Chen, Da-Chun
AU  - Chen DC
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China.
FAU - Tan, Yun-Long
AU  - Tan YL
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China.
FAU - Tan, Shu-Ping
AU  - Tan SP
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China.
FAU - Luo, Xingguang
AU  - Luo X
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
FAU - Zuo, Lingjun
AU  - Zuo L
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
FAU - Soares, Jair C
AU  - Soares JC
AD  - Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric 
      Center, The University of Texas Health Science Center at Houston, Houston, TX, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20151118
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antipsychotic Agents/therapeutic use
MH  - Asian People
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - China
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/drug therapy/*genetics
OTO - NOTNLM
OT  - Association
OT  - BDNF
OT  - Haplotype
OT  - Polymorphism
OT  - Schizophrenia
OT  - Symptoms
EDAT- 2015/11/26 06:00
MHDA- 2016/11/03 06:00
CRDT- 2015/11/26 06:00
PHST- 2015/07/22 00:00 [received]
PHST- 2015/11/07 00:00 [revised]
PHST- 2015/11/10 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/11/03 06:00 [medline]
AID - S0920-9964(15)30052-9 [pii]
AID - 10.1016/j.schres.2015.11.009 [doi]
PST - ppublish
SO  - Schizophr Res. 2016 Jan;170(1):41-7. doi: 10.1016/j.schres.2015.11.009. Epub 2015 
      Nov 18.