PMID- 26603624
OWN - NLM
STAT- MEDLINE
DCOM- 20170714
LR  - 20181113
IS  - 1573-6709 (Electronic)
IS  - 0033-2720 (Linking)
VI  - 87
IP  - 3
DP  - 2016 Sep
TI  - Cognitive Impairment in Schizophrenia: Interplay of BDNF and Childhood Trauma? A 
      Review of Literature.
PG  - 559-69
LID - 10.1007/s11126-015-9409-8 [doi]
AB  - Cognitive impairment is a core feature of schizophrenia. These deficits can also 
      serve as an endophenotype for the illness in genetic studies. There is evidence 
      that suggests that cognition can be considered a reasonable target for 
      intervention in both schizophrenia and bipolar disorder. One of the most studied 
      genetic phenotypes for psychosis is brain-derived neurotrophic factor (BDNF) 
      Val66Met polymorphisms. BDNF has an established role in neuronal development and 
      cell survival in response to stress and is abnormally expressed in schizophrenia. 
      Studies have shown that childhood trauma is associated with poor prognosis of 
      schizophrenic patients. BDNF-Val66Met polymorphism has been shown to moderate the 
      impact of childhood adversity on later expression of affective symptoms, 
      suggesting the possibility of gene environment interactions. Considering the 
      recent advances of neuroscience an up to date review of relevant literature is 
      warranted in this field. This article reviews the current literature available 
      regarding associations between the Val66Met polymorphism, childhood trauma and 
      cognitive dysfunction in schizophrenia.
FAU - Sahu, Geetanjali
AU  - Sahu G
AD  - Department of Psychiatry, Maimonides Medical Center, 4802 Tenth Avenue, Brooklyn, 
      NY, 11219, USA.
FAU - Malavade, Kishor
AU  - Malavade K
AD  - Department of Psychiatry, Maimonides Medical Center, 4802 Tenth Avenue, Brooklyn, 
      NY, 11219, USA.
AD  - Department of Population Health, Maimonides Medical Center, Brooklyn, NY, USA.
FAU - Jacob, Theresa
AU  - Jacob T
AD  - Department of Psychiatry, Maimonides Medical Center, 4802 Tenth Avenue, Brooklyn, 
      NY, 11219, USA. tjacob@maimonidesmed.org.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Psychiatr Q
JT  - The Psychiatric quarterly
JID - 0376465
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult Survivors of Child Adverse Events/*psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognitive Dysfunction/*genetics/psychology
MH  - Endophenotypes
MH  - Gene-Environment Interaction
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Schizophrenia/*genetics
MH  - *Schizophrenic Psychology
OTO - NOTNLM
OT  - BDNF
OT  - BDNFval66met polymorphism
OT  - Childhood trauma
OT  - Cognition in schizophrenia
OT  - Endophenotype
OT  - Genetics
EDAT- 2015/11/26 06:00
MHDA- 2017/07/15 06:00
CRDT- 2015/11/26 06:00
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2017/07/15 06:00 [medline]
AID - 10.1007/s11126-015-9409-8 [pii]
AID - 10.1007/s11126-015-9409-8 [doi]
PST - ppublish
SO  - Psychiatr Q. 2016 Sep;87(3):559-69. doi: 10.1007/s11126-015-9409-8.