PMID- 26603644
OWN - NLM
STAT- MEDLINE
DCOM- 20160915
LR  - 20181202
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 42
DP  - 2016 Jan
TI  - Isoniazid-resistant Mycobacterium kansasii in an HIV-positive patient, and 
      possible development of immune reconstitution inflammatory syndrome after 
      initiation of highly active antiretroviral therapy: case report.
PG  - 40-42
LID - S1201-9712(15)00273-8 [pii]
LID - 10.1016/j.ijid.2015.11.012 [doi]
AB  - Non-tuberculous mycobacteria are rare but important causes of infection in 
      HIV-positive individuals. A 28-year-old HIV-positive male presented with a high 
      fever, non-productive cough, right subcostal pain, splenomegaly, a very low CD4 
      count, elevated C-reactive protein and erythrocyte sedimentation rate, and a 
      normal white blood cell count. The suspicion of tuberculosis (TB) was very high, 
      and sputum samples were positive for acid-fast bacilli. Standard quadruple 
      anti-TB therapy was initiated, but once culture of the sample revealed 
      Mycobacterium kansasii, pyrazinamide was withdrawn. Highly active antiretroviral 
      therapy (HAART) was initiated soon after, consisting of abacavir/lamivudine and 
      efavirenz. The patient's general condition deteriorated 2 weeks after HAART 
      initiation, which could have been due to the development of immune reconstitution 
      inflammatory syndrome (IRIS). The patient recovered and was discharged in good 
      condition. However, the results of resistance testing of the isolated organism 
      arrived after discharge, and showed isoniazid and streptomycin resistance. This 
      is the first case report of M. kansasii infection from Serbia and shows the 
      difficulties encountered during the course of treatment.
CI  - Copyright (c) 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Despotovic, A
AU  - Despotovic A
AD  - Department for HIV/AIDS, University Teaching Hospital for Infectious and Tropical 
      Diseases, Clinical Centre of Serbia, Bul. Oslobodjenja 16, Belgrade, Serbia. 
      Electronic address: alexadespotovic@hotmail.com.
FAU - Savic, B
AU  - Savic B
AD  - Institute for Microbiology and Immunology, National Reference Laboratory for 
      Tuberculosis, Belgrade, Serbia; School of Medicine, University of Belgrade, 
      Serbia.
FAU - Salemovic, D
AU  - Salemovic D
AD  - Department for HIV/AIDS, University Teaching Hospital for Infectious and Tropical 
      Diseases, Clinical Centre of Serbia, Bul. Oslobodjenja 16, Belgrade, Serbia.
FAU - Ranin, J
AU  - Ranin J
AD  - Department for HIV/AIDS, University Teaching Hospital for Infectious and Tropical 
      Diseases, Clinical Centre of Serbia, Bul. Oslobodjenja 16, Belgrade, Serbia; 
      School of Medicine, University of Belgrade, Serbia.
FAU - Jevtovic, Dj
AU  - Jevtovic D
AD  - Department for HIV/AIDS, University Teaching Hospital for Infectious and Tropical 
      Diseases, Clinical Centre of Serbia, Bul. Oslobodjenja 16, Belgrade, Serbia; 
      School of Medicine, University of Belgrade, Serbia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20151201
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Antitubercular Agents)
RN  - V83O1VOZ8L (Isoniazid)
SB  - IM
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Antitubercular Agents/*pharmacology
MH  - HIV Seropositivity/*microbiology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*etiology
MH  - Isoniazid/*pharmacology
MH  - Male
MH  - Mycobacterium kansasii/drug effects/*isolation & purification
OTO - NOTNLM
OT  - IRIS
OT  - Mycobacterial resistance
OT  - Mycobacterium kansasii
OT  - NTM
OT  - Serbia
EDAT- 2015/11/26 06:00
MHDA- 2016/09/16 06:00
CRDT- 2015/11/26 06:00
PHST- 2015/08/31 00:00 [received]
PHST- 2015/11/02 00:00 [revised]
PHST- 2015/11/13 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/09/16 06:00 [medline]
AID - S1201-9712(15)00273-8 [pii]
AID - 10.1016/j.ijid.2015.11.012 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2016 Jan;42:40-42. doi: 10.1016/j.ijid.2015.11.012. Epub 2015 
      Dec 1.